(αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanoic Acid

Base Information

Chemical Name:(αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanoic Acid
CAS No.:483340-19-8
Molecular Formula:C13H13F2N3O3
Molecular Weight:297.26
Hs Code.:
Mol file:483340-19-8.mol

Synonyms:(αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanoic Acid;Isavuconazole interMediate 4

Suppliers and Price of (αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-methyl-1H-1,2,4-triazole-1-butanoicAcid
50mg
$ 865.00

Medical Isotopes, Inc.
(αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-methyl-1H-1,2,4-triazole-1-butanoicAcid
50 mg
$ 1285.00

Crysdot
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoicacid 95+%
250mg
$ 822.00

Crysdot
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoicacid 95+%
100mg
$ 515.00

Ark Pharm
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoicacid 95+%
1g
$ 149.00

Ambeed
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoicacid 95%
5g
$ 524.00

Ambeed
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoicacid 95%
250mg
$ 61.00

Ambeed
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoicacid 95%
100mg
$ 37.00

Total 11 raw suppliers

Chemical Property of (αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanoic Acid

Chemical Property:

Melting Point:191-193 °C(Solv: methanol (67-56-1))
Boiling Point:519.9±60.0 °C(Predicted)
PKA:3.89±0.23(Predicted)
PSA：88.24000
Density:1.43±0.1 g/cm3(Predicted)
LogP:1.16480
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:DCM, Methanol

Purity/Quality:

97% ^*data from raw suppliers

(αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-methyl-1H-1,2,4-triazole-1-butanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-methyl-1H-1,2,4-triazole-1-butanoic Acid is an intermediate in the synthesis of Isavuconazole (I777830), an triazole based antifungal agent for the treatment of invasive fungal infections.

Technology Process of (αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanoic Acid

There total 20 articles about (αR,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoate ethyl ester

: 483340-19-8
3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanoic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 20 ℃; for 10h;

Reference yield: 87.9%

: 944473-05-6
(2R,3R)-3-[3-(2,5-difluorophenyl)-3,4-epoxy-2-methyl]butanoic acid

: 41253-21-8
sodium triazole

: 483340-19-8
(2R,3R)-3-[3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-3-(1H-1,2,4-triazol-1-yl)]butanoic acid

Guidance literature:: In N,N-dimethyl-formamide; at 0 - 60 ℃;
DOI:10.1016/j.tetasy.2007.03.015

Reference yield: 48.0%

: C₁₅H₁₇F₂N₃O₃

: C₁₅H₁₇F₂N₃O₃

: 1558817-06-3,483340-19-8
C₁₃H₁₃F₂N₃O₃

Guidance literature:: With sodium hydroxide; In aq. phosphate buffer; toluene; at 28 ℃; for 26h; pH=7.8; Reagent/catalyst; Solvent; Time; pH-value; Concentration; enantioselective reaction; Resolution of racemate; Enzymatic reaction;