(1-Benzhydryl-3-methylazetidin-3-yl)methanamine

Base Information

• Chemical Name: (1-Benzhydryl-3-methylazetidin-3-yl)methanamine
• CAS No.: 133891-59-5
• Molecular Formula: C18H22N2
• Molecular Weight: 266.38
• DSSTox Substance ID: DTXSID20435754
• Mol file: 133891-59-5.mol

Synonyms:(1-benzhydryl-3-methylazetidin-3-yl)methanamine;133891-59-5;1-(DIPHENYLMETHYL)-3-METHYL-3-AZETIDINEMETHANAMINE;1-[1-(Diphenylmethyl)-3-methylazetidin-3-yl]methanamine;3-aminomethyl-1-diphenylmethyl-3-methylazetidine;SCHEMBL3153086;DTXSID20435754;KTWVMLPQUBNZIM-UHFFFAOYSA-N;AKOS017343165;SB51013;1-Benzhydryl-3-methyl-3-azetidinemethanamine;3-aminomethyl-1-benzhydryl-3-methylazetidine;CS-0444841;FT-0716302

Chemical Property of (1-Benzhydryl-3-methylazetidin-3-yl)methanamine

Chemical Property:

• PSA: 29.26000
• LogP: 3.69480
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 266.178298710
• Heavy Atom Count: 20
• Complexity: 279

Purity/Quality:

97% ^*data from raw suppliers

(1-benzhydryl-3-methylazetidin-3-yl)methanamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CN(C1)C(C2=CC=CC=C2)C3=CC=CC=C3)CN

Technology Process of (1-Benzhydryl-3-methylazetidin-3-yl)methanamine

There total 4 articles about (1-Benzhydryl-3-methylazetidin-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-benzhydryl-3-methylazetidine-3-carbonitrile (133891-88-0) → 3-(aminoethyl)-1-(diphenylmethyl)-3-methylazetidine (133891-59-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/j.bmcl.2007.01.090

Reference yield:

methanesulfonic acid 1-benzhydryl-3-methylazetidin-3-yl ester (133891-87-9) → 3-(aminoethyl)-1-(diphenylmethyl)-3-methylazetidine (133891-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / dimethylformamide; H₂O / 60 °C

2: 95 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.01.090

Reference yield:

1-benzhydryl-3-methylazetidin-3-ol (40320-63-6) → 3-(aminoethyl)-1-(diphenylmethyl)-3-methylazetidine (133891-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / Et₃N

2: 75 percent / dimethylformamide; H₂O / 60 °C

3: 95 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.01.090

upstream raw materials:

1-benzhydryl-3-methylazetidine-3-carbonitrile

1-benzhydryl-3-methylazetidin-3-ol

methanesulfonic acid 1-benzhydryl-3-methylazetidin-3-yl ester

Downstream raw materials:

C₇H₁₁F₃N₂O

1-(diphenylmethyl)-3-methyl-3-(((trifluoroacetyl)amino)methyl)azetidine

3-(aminomethyl)-3-methylazetidine dihydrochloride

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