1-Diphenylmethyl-3-methyl-3-trifluoroacetylaminomethylazetidine

Base Information

Chemical Name:1-Diphenylmethyl-3-methyl-3-trifluoroacetylaminomethylazetidine
CAS No.:133891-58-4
Molecular Formula:C₂₀H₂₁F₃N₂O
Molecular Weight:362.395
Hs Code.:
DSSTox Substance ID:DTXSID401140188

Synonyms:1-diphenylmethyl-3-methyl-3-trifluoroacetylaminomethylazetidine;SCHEMBL5459537;DTXSID401140188;N-(1-Benzhydryl-3-methyl-azetidin-3-ylmethyl)-2,2,2-trifluoro-acetamide;N-[[1-(Diphenylmethyl)-3-methyl-3-azetidinyl]methyl]-2,2,2-trifluoroacetamide;133891-58-4

Suppliers and Price of 1-Diphenylmethyl-3-methyl-3-trifluoroacetylaminomethylazetidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Diphenylmethyl-3-methyl-3-trifluoroacetylaminomethylazetidine

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:362.16059778
Heavy Atom Count:26
Complexity:458

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CN(C1)C(C2=CC=CC=C2)C3=CC=CC=C3)CNC(=O)C(F)(F)F

Technology Process of 1-Diphenylmethyl-3-methyl-3-trifluoroacetylaminomethylazetidine

There total 4 articles about 1-Diphenylmethyl-3-methyl-3-trifluoroacetylaminomethylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 133891-59-5
3-(aminoethyl)-1-(diphenylmethyl)-3-methylazetidine

: 407-25-0
trifluoroacetic anhydride

: 133891-58-4
1-(diphenylmethyl)-3-methyl-3-(((trifluoroacetyl)amino)methyl)azetidine

Guidance literature:: DOI:10.1016/j.bmcl.2007.01.090

Reference yield:

: 133891-88-0
1-benzhydryl-3-methylazetidine-3-carbonitrile

: 133891-58-4
1-(diphenylmethyl)-3-methyl-3-(((trifluoroacetyl)amino)methyl)azetidine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.01.090

Reference yield:

: 133891-87-9
methanesulfonic acid 1-benzhydryl-3-methylazetidin-3-yl ester

: 133891-58-4
1-(diphenylmethyl)-3-methyl-3-(((trifluoroacetyl)amino)methyl)azetidine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / dimethylformamide; H₂O / 60 °C

2: 95 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.01.090