Benzamide, N-cyclopropyl-4-fluoro-2-(oxiranylmethoxy)- (9CI)

Base Information

• Chemical Name: Benzamide, N-cyclopropyl-4-fluoro-2-(oxiranylmethoxy)- (9CI)
• CAS No.: 644968-82-1
• Molecular Formula: C13H14FNO3
• Molecular Weight: 251.2535632
• Mol file: 644968-82-1.mol

Synonyms:Benzamide, N-cyclopropyl-4-fluoro-2-(oxiranylmethoxy)- (9CI)

Chemical Property of Benzamide, N-cyclopropyl-4-fluoro-2-(oxiranylmethoxy)- (9CI)

Chemical Property:

• PSA: 54.35000
• LogP: 2.07030

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide, N-cyclopropyl-4-fluoro-2-(oxiranylmethoxy)- (9CI)

There total 2 articles about Benzamide, N-cyclopropyl-4-fluoro-2-(oxiranylmethoxy)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-cyclopropyl-4-fluoro-2-hydroxybenzamide + (2s)-(+)-glycidyl 3-nitrobenzenesulfonate (115314-14-2) → N-cyclopropyl-4-fluoro-2-(oxiran-2-ylmethoxy)benzamide (644968-82-1)

Guidance literature:

With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

methyl 4-fluoro-2-hydroxybenzoate (392-04-1) → N-cyclopropyl-4-fluoro-2-(oxiran-2-ylmethoxy)benzamide (644968-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 °C

2: caesium carbonate / DMF (N,N-dimethyl-formamide) / 20 °C

With caesium carbonate; In DMF (N,N-dimethyl-formamide);

Reference yield:

N-cyclopropyl-4-fluoro-2-(oxiran-2-ylmethoxy)benzamide (644968-82-1) + 5-chloro-2,3-dihydrospiro (71916-97-7) → 2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-N-cyclopropyl-4-fluorobenzamide

Guidance literature:

In ethanol; at 80 ℃;

upstream raw materials:

(2s)-(+)-glycidyl 3-nitrobenzenesulfonate

methyl 4-fluoro-2-hydroxybenzoate