71916-97-7

Basic information

• Product Name: spiro[benzofuran-2(3H),1'-Methyl-4'-piperidine] hydrobroMide
• Synonyms: spiro[benzofuran-2(3H),1'-Methyl-4'-piperidine] hydrobroMide;5-chloro-2,3-dihydrospiro;5-Chlorospiro[3H-benzofuran-2,4'-piperidine];5-chloro-3h-spiro[benzofuran-2,4'-piperidine] hcl
• CAS NO: 71916-97-7
• Molecular Formula: C₁₂H₁₄ClNO
• Molecular Weight: 260.1596
• Mol File: 71916-97-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: spiro[benzofuran-2(3H),1'-Methyl-4'-piperidine] hydrobroMide(CAS DataBase Reference)
• NIST Chemistry Reference: spiro[benzofuran-2(3H),1'-Methyl-4'-piperidine] hydrobroMide(71916-97-7)
• EPA Substance Registry System: spiro[benzofuran-2(3H),1'-Methyl-4'-piperidine] hydrobroMide(71916-97-7)

Safety Data

• Hazardous Substances Data: 71916-97-7(Hazardous Substances Data)

Upstream product

• 71916-95-5 1'-benzyl-5-chloro-2,3-dihydrospiro 
• 1003567-30-3 5-chloro-3H-spiro[1-benzofuran-2,4'-piperidine] hydrobromic acid salt 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 147804-30-6 1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester 
• 1055710-50-3 C₁₇H₂₃ClFNO₃ 
• 1996-30-1 2-bromo-4-chloro-1-fluorobenzene 
• 644967-79-3 5-chlorospiro[1-benzofuran-2,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester 
• 71916-91-1 5-chloro-2-fluorobenzyl bromide 
• 71916-92-2 1-benzyl-4-(5-chloro-2-fluorobenzyl)-4-piperidinol 

Downstream Products

• 1003567-11-0 5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-(p-methoxybenzyloxy)-N-methylbenzamide 
• 644968-71-8 N-(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methoxyphenyl)acetamide 
• 644969-50-6 methyl 2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-[(4-methoxybenzyl)oxy]benzoate 
• 644970-90-1 tert-butyl 2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}benzoate 
• 1427190-05-3 C₂₄H₃₀ClN₃O₄ 

Relevant articles and documents

Spirocyclic compounds, potent CCR1 antagonists

Conformationally constrained spirocycles (17-23) and (31-36) were synthesised. In vitro data revealed that these compounds are CCR1 antagonists with sub-nanomolar potency. In a functional assay 22, 23 and 36 inhibited CCR1 mediated chemotaxis with an ICs

A PROCESS FOR THE PREPARATION OF INTERMEDIATES AND THEIR US IN THE SYNTHESIS OF SPIROPIPERIDINE COMPOUNDS

The present invention relates to new processes for the preparation of compounds of formula I, especially the compound 2-{2-Chloro-5-{[(2S)-3-(5-chloro-1'H,3H-spiro[l- benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-5[(methylamino)carbonyl]phenoxy}-2-methylpropanoic acid and to new intermediates useful in the preparation thereof.

NOVEL COMPOUNDS

The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, t, R3, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their