R-3-3'-Bis(3,5-bis(methyl)phenyl)-1,1'-bi-2-naphthol

Base Information

• Chemical Name: R-3-3'-Bis(3,5-bis(methyl)phenyl)-1,1'-bi-2-naphthol
• CAS No.: 215433-51-5
• Molecular Formula: C₃₆H₃₀O₂
• Molecular Weight: 494.633
• Hs Code.: 2908190090
• Mol file: 215433-51-5.mol

Synonyms:R-3-3'-Bis(3,5-bis(methyl)phenyl)-1,1'-bi-2-naphthol;(R)-3,3'-Bis(3,5-dimethylphenyl)-1,1'-bi-2-napthalene]-2,2'-diol;(R)-3,3'-Bis(3,5-dimethylphenyl)-1,1'-bi-2-naphthalene]-2,2'-diol

Chemical Property of R-3-3'-Bis(3,5-bis(methyl)phenyl)-1,1'-bi-2-naphthol

Chemical Property:

• Melting Point: 124-125 °C
• Boiling Point: 597.0±45.0 °C(Predicted)
• PKA: 8.07±0.50(Predicted)
• PSA: 40.46000
• Density: 1.190±0.06 g/cm3(Predicted)
• LogP: 9.63880

Purity/Quality:

97% ^*data from raw suppliers

(R)-3,3'-Bis(3,5-dimethylphenyl)-1,1'-bi-2-napthalene]-2,2'-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of R-3-3'-Bis(3,5-bis(methyl)phenyl)-1,1'-bi-2-naphthol

There total 29 articles about R-3-3'-Bis(3,5-bis(methyl)phenyl)-1,1'-bi-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(+/-)-3,3'-bis(3,5-dimethylphenyl)-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl (756491-46-0) → (+/-)-3,3'-bis(3,5-dimethylphenyl)-2,2'-dihydroxy-1,1'-binaphthyl (215433-51-5)

Guidance literature:

With Amberlyst 15 resin; In tetrahydrofuran; methanol; for 15h; Heating;

DOI:10.1021/ol0490882

Reference yield: 91.0%

(R)-2,2'-bis(benzyloxy)-3,3'-bis(3,5-dimethylphenyl)-1,1'-binaphthalene → (R)-3,3′-bis(3,5-dimethylphenyl)-2,2′-dihydroxy-1,1′-dinaphthyl (215433-51-5)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 24h; under 760.051 Torr;

DOI:10.1021/jacs.9b13117

Reference yield: 88.0%

1-chloro-3,5-dimethylbenzene (556-97-8) + (Ra)-2,2'-bis(methoxy-methyloxy)-1,1'-binaphthalene → (R)-3,3′-bis(3,5-dimethylphenyl)-2,2′-dihydroxy-1,1′-dinaphthyl (215433-51-5)

Guidance literature:

1-chloro-3,5-dimethylbenzene; (Ra)-2,2'-bis(methoxy-methyloxy)-1,1'-binaphthalene; With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; tert.-butyl lithium; In n-heptane; at 20 ℃; for 0.166667h; Schlenk technique;

In n-heptane; Schlenk technique; Acidic conditions;

DOI:10.1002/anie.201707760

upstream raw materials:

(R)-1,1'-Bi-2-naphthol

5-bromo-1,3-xylene

(R)-2,2'-dimethoxy-1,1'-dinaphthyl

1-chloro-3,5-dimethylbenzene