2,2-Dimethylpyrrolidine hydrochloride

Base Information

• Chemical Name: 2,2-Dimethylpyrrolidine hydrochloride
• CAS No.: 623580-01-8
• Molecular Formula: C₆H₁₃N*ClH
• Molecular Weight: 135.637
• Hs Code.: 2933990090
• Mol file: 623580-01-8.mol

Synonyms:2,2-Dimethylpyrrolidine hydrochloride

Chemical Property of 2,2-Dimethylpyrrolidine hydrochloride

Chemical Property:

• Vapor Pressure: 2.56mmHg at 25°C
• Boiling Point: 156.3°C at 760 mmHg
• Flash Point: 48.4°C
• PSA: 12.03000
• LogP: 2.27920
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2,2-DimethylpyrrolidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,2-Dimethylpyrrolidine Hydrochloride is used in the preparation of bicyclic and spirocyclic compounds as KDM5 inhibitors.

Technology Process of 2,2-Dimethylpyrrolidine hydrochloride

There total 4 articles about 2,2-Dimethylpyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

2-azido-2-methylpentane (91633-21-5) → 2,2-dimethylpyrrolidine hydrogen chloride (623580-01-8)

Guidance literature:

2-azido-2-methylpentane; With (1,9-di(1-adamantyl)-5-perfluorophenyldipyrrin)Ni(pyridine); In benzene-d6; at 80 ℃; for 48h;

With hydrogenchloride; In water;

DOI:10.1021/jacs.0c02126

Reference yield:

5,5-Dimethyl-1-pyrroline N-oxide (3317-61-1) → 2,2-dimethylpyrrolidine hydrogen chloride (623580-01-8)

Guidance literature:

5,5-Dimethyl-1-pyrroline N-oxide; With hydrogen; palladium 10% on activated carbon; In ethanol; under 3000.3 Torr;

With hydrogenchloride; In 1,4-dioxane; ethanol;

Reference yield:

5,5-dimethyl-2-pyrrolidone (5165-28-6,2484-97-1) → 2,2-dimethylpyrrolidine hydrogen chloride (623580-01-8)

Guidance literature:

5,5-dimethyl-2-pyrrolidone; With lithium aluminium tetrahydride; In tetrahydrofuran; for 16h; Heating / reflux;

With sodium hydroxide; water; In tetrahydrofuran; at 0 ℃; for 0.75h;

With hydrogenchloride; In tetrahydrofuran; diethyl ether;

upstream raw materials:

5,5-dimethyl-2-pyrrolidone

5,5-Dimethyl-1-pyrroline N-oxide

2-methylpentan-2-ol

2-azido-2-methylpentane

Downstream raw materials:

1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine

Refernces

• 1、 -. "Novel Compounds 951". Page/Page column 7. . Retrieved 2009/01/23.