1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine

Base Information

• Chemical Name: 1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine
• CAS No.: 1097085-12-5
• Molecular Formula: C₂₀H₂₁ClFNO₂
• Molecular Weight: 361.844
• Mol file: 1097085-12-5.mol

Synonyms:1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine

Chemical Property of 1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine

There total 2 articles about 1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethyl-pyrrolidine (35018-15-6) + C14H9Cl2FO2 → 1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine (1097085-12-5)

Guidance literature:

With triethylamine; In ethyl acetate; at 10 - 23 ℃; for 1h; Product distribution / selectivity;

Reference yield:

2,2-dimethylpyrrolidine hydrogen chloride (623580-01-8) + C14H9Cl2FO2 → 1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine (1097085-12-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Product distribution / selectivity;

Reference yield:

1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine (1097085-12-5) → 3'-Chloro-4'-[(2,2-dimethylpyrrolidin-1-yl)carbonyl]-5-fluorobiphenyl-2-ol (1097085-13-6)

Guidance literature:

1-[(3-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl)carbonyl]-2,2-dimethylpyrrolidine; With boron tribromide; In dichloromethane; at 20 ℃;

With water; In dichloromethane; Product distribution / selectivity;

upstream raw materials:

2,2-dimethyl-pyrrolidine

2,2-dimethylpyrrolidine hydrogen chloride

Downstream raw materials:

3'-Chloro-4'-[(2,2-dimethylpyrrolidin-1-yl)carbonyl]-5-fluorobiphenyl-2-ol

Refernces