8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Base Information

Chemical Name:8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
CAS No.:1607837-31-9
Molecular Formula:C21H23ClN6O
Molecular Weight:410.9
Hs Code.:
Mol file:1607837-31-9.mol

Synonyms:8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one;CCT-251921

Suppliers and Price of 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
CCT251921 >98%
1 g
$ 2600.00

DC Chemicals
CCT251921 >98%
100 mg
$ 750.00

Crysdot
CCT251921 97%
10mg
$ 515.00

Crysdot
CCT251921 97%
50mg
$ 1496.00

ChemScene
CCT-251921 99.77%
50mg
$ 1140.00

ChemScene
CCT-251921 99.77%
25mg
$ 840.00

ChemScene
CCT-251921 99.77%
10mg
$ 420.00

ChemScene
CCT-251921 99.77%
1mg
$ 108.00

Total 7 raw suppliers

Chemical Property of 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Chemical Property:

PSA：89.07000
LogP:3.95240

Purity/Quality:

97% ^*data from raw suppliers

CCT251921 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

There total 10 articles about 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 8-(2-(bis(4-methoxybenzyl)amino)-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

: 1607837-31-9
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Guidance literature:: With trifluoroacetic acid; at 20 ℃;
DOI:10.1016/j.ejmech.2021.113391

Reference yield: 24.0%

: 1607838-02-7
8-(3-chloro-2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

: 1607837-31-9
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Guidance literature:: With hydroxylamine hydrochloride; In ethanol; water; for 8h; Reflux;

Reference yield:

: 19798-80-2
2-Amino-4-chloropyridine

: 1607837-31-9
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / acetonitrile / 3 h / 20 °C / Inert atmosphere

2: N-chloro-succinimide / acetonitrile / 3 h / 95 °C / Inert atmosphere

3: toluene-4-sulfonic acid / toluene / 5 h / Reflux

4: 1-methyl-pyrrolidin-2-one; triethylamine / 1 h / 220 °C / Microwave irradiation; Inert atmosphere

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / acetonitrile; water / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

6: hydroxylamine hydrochloride / water; ethanol / 8 h / Reflux

With 1-methyl-pyrrolidin-2-one; N-chloro-succinimide; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydroxylamine hydrochloride; sodium carbonate; toluene-4-sulfonic acid; triethylamine; In ethanol; water; toluene; acetonitrile;