5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine

Base Information

• Chemical Name: 5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine
• CAS No.: 1607838-03-8
• Molecular Formula: C₂₁H₁₉BrCl₂N₂O₂
• Molecular Weight: 482.204
• Mol file: 1607838-03-8.mol

Synonyms:5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine

Chemical Property of 5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine

There total 4 articles about 5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-bromo-3,4-dichloropyridin-2-amine (1607837-98-8) + p-methoxybenzyl chloride (824-94-2) → 5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine (1607838-03-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; paraffin oil; at 20 ℃; for 2h;

Reference yield: 66.0%

5-bromo-3,4-dichloropyridin-2-amine (1607837-98-8) + p-methoxybenzyl chloride (824-94-2) → 5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine (1607838-03-8) + 5-bromo-3,4-dichloro-N-(4-methoxybenzyl)pyridin-2-amine

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 2.25h;

DOI:10.1016/j.ejmech.2021.113391

Reference yield:

2-Amino-4-chloropyridine (19798-80-2) → 5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine (1607838-03-8)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / acetonitrile / 3 h / 20 °C / Inert atmosphere

2: N-chloro-succinimide / acetonitrile / 3 h / 95 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 2 h / 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; sodium hydride; In N,N-dimethyl-formamide; acetonitrile; paraffin oil;

upstream raw materials:

5-bromo-3,4-dichloropyridin-2-amine

p-methoxybenzyl chloride

2-Amino-4-chloropyridine

5-bromo-4-chloro-pyridin-2-ylamine

Downstream raw materials:

8-[2-[bis-(4-methoxybenzyl)amino]-3-chloro-5-(2-ethyl-1,1-dioxo-2,3-dihydro-1H-benzo[d]isothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one

8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

8-(2-(bis(4-methoxybenzyl)amino)-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione

8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione