Ethyl 2-(4-bromophenyl)-2-methylpropanoate

Base Information

Chemical Name:Ethyl 2-(4-bromophenyl)-2-methylpropanoate
CAS No.:32454-36-7
Molecular Formula:C12H15BrO2
Molecular Weight:271.154
Hs Code.:2916399090
DSSTox Substance ID:DTXSID80460986
Wikidata:Q82285194
Mol file:32454-36-7.mol

Synonyms:ethyl 2-(4-bromophenyl)-2-methylpropanoate;32454-36-7;Ethyl2-(4-bromophenyl)-2-methylpropanoate;SCHEMBL9211;DTXSID80460986;XTSCLIBGCPXCLH-UHFFFAOYSA-N;AKOS016845075;DS-7099;CS-0151894;C74658;EN300-372910;J-520611;2-(4-bromo-phenyl)-2-methyl-propionic acid ethyl ester

Suppliers and Price of Ethyl 2-(4-bromophenyl)-2-methylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl2-?(4-?Bromophenyl)?-?2-?methylpropanoate
100mg
$ 100.00

TRC
Ethyl2-?(4-?Bromophenyl)?-?2-?methylpropanoate
500mg
$ 210.00

Crysdot
Ethyl2-(4-bromophenyl)-2-methylpropanoate 95+%
1g
$ 380.00

American Custom Chemicals Corporation
ETHYL-2-(4-BROMOPHENYL)-2-METHYLPROPANOATE 95.00%
5MG
$ 498.69

Ambeed
Ethyl2-(4-bromophenyl)-2-methylpropanoate 95%
1g
$ 153.00

Ambeed
Ethyl2-(4-bromophenyl)-2-methylpropanoate 95%
250mg
$ 58.00

Ambeed
Ethyl2-(4-bromophenyl)-2-methylpropanoate 95%
100mg
$ 30.00

Total 7 raw suppliers

Chemical Property of Ethyl 2-(4-bromophenyl)-2-methylpropanoate

Chemical Property:

PSA：26.30000
LogP:3.28980
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:270.02554
Heavy Atom Count:15
Complexity:218

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-?(4-?Bromophenyl)?-?2-?methylpropanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C)(C)C1=CC=C(C=C1)Br
Uses Ethyl 2-?(4-?Bromophenyl)?-?2-?methylpropanoate is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Technology Process of Ethyl 2-(4-bromophenyl)-2-methylpropanoate

There total 3 articles about Ethyl 2-(4-bromophenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 14062-25-0
Ethyl 4-bromophenylacetate

: 74-88-4
methyl iodide

: 32454-36-7
2-(4-bromophenyl)-2-methyl-propionic acid ethyl ester

Guidance literature:: Ethyl 4-bromophenylacetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 74-88-4
methyl iodide

: 32454-36-7
2-(4-bromophenyl)-2-methyl-propionic acid ethyl ester

Guidance literature:: Ethyl 4-bromophenylacetate; With sodium hydride; In tetrahydrofuran; at 20 - 23 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 2h;