Glycine, N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-N-(Methylsulfonyl)-

Base Information

• Chemical Name: Glycine, N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-N-(Methylsulfonyl)-
• CAS No.: 1335206-40-0
• Molecular Formula: C20H22N2O6S
• Molecular Weight: 418.46348
• Hs Code.: 2935009090
• Mol file: 1335206-40-0.mol

Synonyms:Glycine, N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-N-(Methylsulfonyl)-;2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)methylsulfonamido)acetic acid

Chemical Property of Glycine, N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-N-(Methylsulfonyl)-

Chemical Property:

• PKA: 3.37±0.10(Predicted)
• PSA: 124.88000
• Density: 1.378±0.06 g/cm3(Predicted)
• LogP: 3.15650

Purity/Quality:

98%,99%, ^*data from raw suppliers

glycine,n-[2-[[(9h-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]-n-(methylsulfonyl)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-N-(Methylsulfonyl)-

There total 2 articles about Glycine, N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-N-(Methylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl N-methylsulfonamido]glycinate → 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)methylsulfonamido)acetic acid (1335206-40-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride (169396-88-7) → 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)methylsulfonamido)acetic acid (1335206-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

2: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1002/pep2.24199

upstream raw materials:

tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride

Refernces

• 1、 -. "Integrin interaction inhibitors for the treatment of cancer". Page/Page column 40. . Retrieved 2018/09/14.