N-[2-(FMOC-AMINO)-ETHYL]GLYCINE TERT-BUTYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: N-[2-(FMOC-AMINO)-ETHYL]GLYCINE TERT-BUTYL ESTER HYDROCHLORIDE
• CAS No.: 169396-88-7
• Molecular Formula: C₂₃H₂₈N₂O₄*ClH
• Molecular Weight: 432.947
• Hs Code.: 2924299090
• Mol file: 169396-88-7.mol

Synonyms:Glycine,N-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]-, 1,1-dimethylethyl ester,monohydrochloride (9CI);

Chemical Property of N-[2-(FMOC-AMINO)-ETHYL]GLYCINE TERT-BUTYL ESTER HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 7.28E-14mmHg at 25°C
• Boiling Point: 582.5 °C at 760 mmHg
• Flash Point: 306.1 °C
• PSA: 76.66000
• LogP: 5.04020
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-[2-(Fmoc-amino)-ethyl]glycinetert-butylesterhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Building block for preparing FMOC-protected PNA (Peptide Nucleic Acid) monomers.

Technology Process of N-[2-(FMOC-AMINO)-ETHYL]GLYCINE TERT-BUTYL ESTER HYDROCHLORIDE

There total 6 articles about N-[2-(FMOC-AMINO)-ETHYL]GLYCINE TERT-BUTYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (2-aminoethylamino)acetic acid tert-butyl ester (104732-23-2) → tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride (169396-88-7)

Guidance literature:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; (2-aminoethylamino)acetic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

With hydrogenchloride; In water;

Reference yield: 90.0%

9-fluorenylmethyl N-succinimidyl carbonate (102774-86-7) + (2-aminoethylamino)acetic acid tert-butyl ester (104732-23-2) → tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride (169396-88-7)

Guidance literature:

9-fluorenylmethyl N-succinimidyl carbonate; (2-aminoethylamino)acetic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

With hydrogenchloride; In water; at -20 ℃;

DOI:10.1002/pep2.24199

Reference yield:

tert-Butyl N-(2-aminoethyl)glycine + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → tert-butyl N-[2-(N-9-fluorenylmethoxycarbonyl)aminoethyl]glycinate hydrochloride (169396-88-7)

Guidance literature:

With sodium sulfate;

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(2-aminoethylamino)acetic acid tert-butyl ester

tert-Butyl chloroacetate

tert-butyl N-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethyl)glycinate

Downstream raw materials:

2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid

C₃₉H₄₂N₈O₇

C₃₈H₄₂N₆O₈

2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)methylsulfonamido)acetic acid

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