alentamol

Base Information

• Chemical Name: alentamol
• CAS No.: 121514-27-0
• Molecular Formula: BrH*C₁₉H₂₅NO
• Molecular Weight: 364.326
• Mol file: 121514-27-0.mol

Synonyms:1H-Phenalen-5-ol,2-(dipropylamino)-2,3-dihydro-, hydrobromide (9CI); U 66444B

Chemical Property of alentamol

Chemical Property:

• Vapor Pressure: 3.08E-09mmHg at 25°C
• Boiling Point: 464.2°C at 760 mmHg
• Flash Point: 238.3°C
• PSA: 23.47000
• LogP: 5.09270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Therapeutic Function: Antipsychotic, Dopamine agonist

Technology Process of alentamol

There total 12 articles about alentamol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(5-Methoxy-2,3-dihydro-1H-phenalen-2-yl)-dipropyl-amine (112892-47-4,112892-48-5,112892-53-2) → 2-(di-n-propylamino)-2,3-dihydro-1H-phenalene-5-ol*HBr (112892-51-0,112892-81-6,121514-28-1,121514-27-0)

Guidance literature:

With hydrogen bromide; In water; at 120 ℃;

DOI:10.1016/S0040-4039(00)82068-7

Reference yield:

2-hydroxy-5-methoxybenzaldehyde (672-13-9) → 2-(di-n-propylamino)-2,3-dihydro-1H-phenalene-5-ol*HBr (112892-51-0,112892-81-6,121514-28-1,121514-27-0)

Guidance literature:

Multi-step reaction with 12 steps

1: 81 percent / Br₂, NaOAc / acetic acid

2: NaOH / tetrahydrofuran

3: Skeilysolve B / acetic acid

4: 65 percent / SiO₂ / CH₂Cl₂

5: aluminum hydride / tetrahydrofuran

6: propionic acid / benzene

7: phenyllithium / tetrahydrofuran / 2 h / 10 °C

8: 74 percent / H₂ / 10 percent Pd/C / tetrahydrofuran

9: 75 percent / BF₃*Et₂O

10: 79 percent / hydroxylamine hydrochloride, sodium bicarbonate / ethanol / Heating

11: 66 percent / potassium carbonate / acetonitrile / Heating

12: 63 percent / 48 percent HBr / H₂O / 120 °C

With aluminium hydride; sodium hydroxide; hexane; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; bromine; sodium acetate; silica gel; sodium hydrogencarbonate; potassium carbonate; propionic acid; phenyllithium; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; acetonitrile; benzene;

DOI:10.1016/S0040-4039(00)82068-7

Reference yield:

3-Bromo-2-hydroxy-5-methoxy-benzaldehyde (50343-02-7) → 2-(di-n-propylamino)-2,3-dihydro-1H-phenalene-5-ol*HBr (112892-51-0,112892-81-6,121514-28-1,121514-27-0)

Guidance literature:

Multi-step reaction with 11 steps

1: NaOH / tetrahydrofuran

2: Skeilysolve B / acetic acid

3: 65 percent / SiO₂ / CH₂Cl₂

4: aluminum hydride / tetrahydrofuran

5: propionic acid / benzene

6: phenyllithium / tetrahydrofuran / 2 h / 10 °C

7: 74 percent / H₂ / 10 percent Pd/C / tetrahydrofuran

8: 75 percent / BF₃*Et₂O

9: 79 percent / hydroxylamine hydrochloride, sodium bicarbonate / ethanol / Heating

10: 66 percent / potassium carbonate / acetonitrile / Heating

11: 63 percent / 48 percent HBr / H₂O / 120 °C

With aluminium hydride; sodium hydroxide; hexane; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; silica gel; sodium hydrogencarbonate; potassium carbonate; propionic acid; phenyllithium; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; acetonitrile; benzene;

DOI:10.1016/S0040-4039(00)82068-7

upstream raw materials:

(5-Methoxy-2,3-dihydro-1H-phenalen-2-yl)-dipropyl-amine

2-hydroxy-5-methoxybenzaldehyde

3-Bromo-2-hydroxy-5-methoxy-benzaldehyde

5-Methoxy-2,3-dihydro-1H-phenalen-2-ylamine

Refernces