5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate Maleate

Base Information

• Chemical Name: 5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate Maleate
• CAS No.: 1373350-61-8
• Molecular Formula: C₄H₄O₄*C₂₀H₂₁ClFNO₃S
• Molecular Weight: 525.982
• Mol file: 1373350-61-8.mol

Synonyms:5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate Maleate

Chemical Property of 5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate Maleate

Chemical Property:

• PSA: 149.45000
• LogP: 4.14970
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-ylAcetateMaleate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate Maleate is is an impurity of Prasugrel (P701150). 5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate Maleate is an impurity of Prasugrel (P701150).

Technology Process of 5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate Maleate

There total 6 articles about 5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate Maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.5%

2-acetoxy-5-[5-chloro-1-(2-fluorophenyl)-2-oxopentyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (1056459-37-0) + 2-butenedioic acid (6915-18-0,26099-09-2) → 2-acetoxy-5-[5-chIoro-1-(2-fluorophenyl)pentyl]-4,5,6,7-tetrahydro-4H-thieno[3,2-c] pyridine maleate (1373350-61-8)

Guidance literature:

In acetone;

Reference yield:

5-triphenylmethyl-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine (109904-26-9) → 2-acetoxy-5-[5-chIoro-1-(2-fluorophenyl)pentyl]-4,5,6,7-tetrahydro-4H-thieno[3,2-c] pyridine maleate (1373350-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 6 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h

2.2: 1 h / 15 - 20 °C

3.1: acetone

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

Reference yield:

1-cyclopropyl-2-(2-fluorophenyl)ethanone (150322-73-9) → 2-acetoxy-5-[5-chIoro-1-(2-fluorophenyl)pentyl]-4,5,6,7-tetrahydro-4H-thieno[3,2-c] pyridine maleate (1373350-61-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 3 h

2.1: toluene-4-sulfonic acid; N-Bromosuccinimide / 0.5 h / 40 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h

3.2: 1 h / 15 - 20 °C

4.1: acetone

With hydrogenchloride; N-Bromosuccinimide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; acetone;

upstream raw materials:

2-acetoxy-5-[5-chloro-1-(2-fluorophenyl)-2-oxopentyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

2-butenedioic acid

6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride

1-cyclopropyl-2-(2-fluorophenyl)ethanone

Refernces