Cyclopropyl 2-fluorobenzyl ketone

Base Information

• Chemical Name: Cyclopropyl 2-fluorobenzyl ketone
• CAS No.: 150322-73-9
• Molecular Formula: C11H11FO
• Molecular Weight: 178.206
• Hs Code.: 2914700090
• Mol file: 150322-73-9.mol

Synonyms:1-Cyclopropyl-2-(2-fluorophenyl)ethanone;

Chemical Property of Cyclopropyl 2-fluorobenzyl ketone

Chemical Property:

• Appearance/Colour: Pale Yellow Oil
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.549
• Boiling Point: 253.597 °C at 760 mmHg
• Flash Point: 107.942 °C
• PSA: 17.07000
• Density: 1.192 g/cm³
• LogP: 2.34730
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig

Purity/Quality:

99% ^*data from raw suppliers

Cyclopropyl 2-Fluorobenzyl Ketone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Cyclopropyl 2-fluorobenzyl ketone is a kind of ketone derivative. It is a kind of pharmacological intermediate. It is a pharmacological intermediate during the preparation of Prasugrel which is a kind of platelet inhibitors used for preventing the formation of blood clots.
• Uses: Atomoxetine intermediate Prasugrel intermediate. Prasugrel intermediate

Technology Process of Cyclopropyl 2-fluorobenzyl ketone

There total 23 articles about Cyclopropyl 2-fluorobenzyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

1-(2-fluorophenyl)but-3-en-2-one + dimethylsulfoxonium methylide (70775-39-2,5367-24-8) → 1-cyclopropyl-2-(2-fluorophenyl)ethanone (150322-73-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h; Temperature;

Reference yield: 92.0%

cyclopropanecarboxylic acid chloride (4023-34-1) + methyl o-fluorophenylacetate (57486-67-6) → 1-cyclopropyl-2-(2-fluorophenyl)ethanone (150322-73-9)

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 - 60 ℃; for 6h; Solvent; Reagent/catalyst; Temperature;

Reference yield: 91.4%

o-fluorophenylacetic acid ethyl ester (584-74-7) + cyclopropanecarboxylic acid chloride (4023-34-1) → 1-cyclopropyl-2-(2-fluorophenyl)ethanone (150322-73-9)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 20 - 30 ℃; for 8h; Solvent; Reagent/catalyst; Temperature;

upstream raw materials:

o-fluorobenzyl bromide

magnesium dihydride

cyclopropropanecarbonitrile

cyclopropanecarboxylic acid chloride

Downstream raw materials:

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

α-cyclopropylcarbonyl-2-fluorobenzyl chloride

5-chloro-1-(2-fluorophenyl)-pentan-2-one

prasugel

Refernces

• 1、 -. "2 - Bromo 2 - (2 - fluorophenyl) ethanone preparation of cyclopropyl (by machine translation)". Paragraph 0038; 0045; 0046; 0054. . Retrieved 2018/04/26.
• 2、 Moon, Patrick J.,Yin, Shengkang,Lundgren, Rylan J.. "Ambient Decarboxylative Arylation of Malonate Half-Esters via Oxidative Catalysis". supporting information. p. 13826 - 13829. Retrieved 2016/11/06.