(6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL

Base Information

• Chemical Name: (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL
• CAS No.: 197847-92-0
• Molecular Formula: C13H10F3NO2
• Molecular Weight: 269.22
• Mol file: 197847-92-0.mol

Synonyms:(6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL;6-[3-(TRIFLUOROMETHOXY)PHENYL]-3-PYRIDINEMETHANOL

Chemical Property of (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL

Chemical Property:

• PSA: 42.35000
• LogP: 3.13950

Purity/Quality:

97% ^*data from raw suppliers

(6-(3-(TRIFLUOROMETHOXY)PHENYL)PYRIDIN-3-YL)METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL

There total 4 articles about (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-(3-(trifluoromethoxy)phenyl)nicotinaldehyde (898796-59-3) → (6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)methanol (197847-92-0)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01372

Reference yield:

2-(3-trifluoromethoxyphenyl)-5-carboxy pyridine (197847-91-9) + sodium sulfate (7757-82-6) → (6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)methanol (197847-92-0)

Guidance literature:

In tetrahydrofuran; ethyl acetate;

Reference yield:

6-bromonicotinaldehyde (149806-06-4) → (6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)methanol (197847-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 0.08 h / 20 °C

1.2: 18 h / 80 °C

2.1: sodium tetrahydroborate / ethanol / 0.5 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; ethanol; water; 1.2: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.0c01372

upstream raw materials:

2-(3-trifluoromethoxyphenyl)-5-carboxy pyridine

sodium sulfate

6-(3-(trifluoromethoxy)phenyl)nicotinaldehyde

(3-(trifluoromethoxy)phenyl)boronic acid

Downstream raw materials:

1-(2-(3-Trifluoromethoxyphenyl)-pyrid-5-ylmethyl)-5-(4-cyanobenzyl)imidazole