1-(4-(Chloromethyl)phenyl)-1H-imidazole

Base Information

• Chemical Name: 1-(4-(Chloromethyl)phenyl)-1H-imidazole
• CAS No.: 789445-30-3
• Molecular Formula: C10H9ClN2
• Molecular Weight: 192.64486
• Hs Code.: 2933290090
• DSSTox Substance ID: DTXSID10427683
• Wikidata: Q82240340
• Mol file: 789445-30-3.mol

Synonyms:1-(4-(Chloromethyl)phenyl)-1H-imidazole;789445-30-3;1-[4-(chloromethyl)phenyl]imidazole;1-[4-(chloromethyl)phenyl]-1H-imidazole;SCHEMBL2460217;DTXSID10427683;DJAJKNDOAPELFN-UHFFFAOYSA-N;MFCD07352297;AKOS009035841;F30990;A864945;Z111874942

Chemical Property of 1-(4-(Chloromethyl)phenyl)-1H-imidazole

Chemical Property:

• PSA: 17.82000
• LogP: 2.61110
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 192.0454260
• Heavy Atom Count: 13
• Complexity: 155

Purity/Quality:

97% ^*data from raw suppliers

1-(4-(Chloromethyl)phenyl)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CCl)N2C=CN=C2

Technology Process of 1-(4-(Chloromethyl)phenyl)-1H-imidazole

There total 1 articles about 1-(4-(Chloromethyl)phenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(Hydroxymethyl)-4-(1H-imidazol-1-yl)benzene (86718-08-3) → 1-(4-(chloromethyl) phenyl)-1H-imidazole (789445-30-3)

Guidance literature:

1-(Hydroxymethyl)-4-(1H-imidazol-1-yl)benzene; With dmap; N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride; In dichloromethane; at 20 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield:

1-(4-(chloromethyl) phenyl)-1H-imidazole (789445-30-3) + 4-diazo-2,5-bis(2-fluorophenyl)-2,4-dihydro-3H-pyrazol-3-one (1240912-10-0) → 9-fluoro-2-(2-fluorophenyl)-5-{[4-(1H-imidazol-1-yl)phenyl]methyl}-2,5-dihydro-3H-pyrazolo[4,3-c]cinnolin-3-one

Guidance literature:

4-diazo-2,5-bis(2-fluorophenyl)-2,4-dihydro-3H-pyrazol-3-one; With tributylphosphine; In acetonitrile; at 20 ℃; for 0.5h;

1-(4-(chloromethyl) phenyl)-1H-imidazole; With potassium carbonate; potassium iodide; In acetonitrile; at 20 - 85 ℃;

Reference yield:

1-(4-(chloromethyl) phenyl)-1H-imidazole (789445-30-3) + 4-ethyl-2-mercapto-6-(4-methyl-1,4-diazepan-1-yl)pyridine-3,5-dicarbonitrile → 2-((4-(1H-imidazol-1-yl)benzyl)thio)-4-ethyl-6-(4-methyl-1,4-diazepan-1-yl)pyridine-3,5-dicarbonitrile

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

1-(Hydroxymethyl)-4-(1H-imidazol-1-yl)benzene

Downstream raw materials:

1-<4-(aminomethyl)phenyl>-1H-imidazole