86718-08-3

Basic information

• Product Name: [4-(1H-Imidazol-1-yl)phenyl]methanol
• Synonyms: RARECHEM AL BD 0793;BUTTPARK 98\50-49;(4-IMIDAZOL-1-YL-PHENYL)METHANOL;4-(1-IMIDAZOLYL)BENZYLALCOHOL;[4-(1H-IMIDAZOL-1-YL)PHENYL]METHANOL;4-(1H-Imidazol-1-yl)benzyl alcohol;1-(4-Hydroxymethyl-phenyl)imidazole;[4-(1-IMidazolyl)phenyl]Methanol
• CAS NO: 86718-08-3
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Product Categories: Alcohols and Derivatives;Heterocycles
• Mol File: 86718-08-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 364.9°Cat760mmHg
• Flash Point: 174.5°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 5.75E-06mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.07±0.10(Predicted)
• CAS DataBase Reference: [4-(1H-Imidazol-1-yl)phenyl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(1H-Imidazol-1-yl)phenyl]methanol(86718-08-3)
• EPA Substance Registry System: [4-(1H-Imidazol-1-yl)phenyl]methanol(86718-08-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-41
• Safety Statements: 36/37-39-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 86718-08-3(Hazardous Substances Data)

Usage

General Description

"[4-(1H-Imidazol-1-yl)phenyl]methanol" is a chemical compound with the molecular formula C10H11NO. It is also known by the name "N-((1H-Imidazol-1-yl)phenyl)methanol" and is a derivative of imidazole. [4-(1H-Imidazol-1-yl)phenyl]methanol is a white to off-white crystalline powder that is sparingly soluble in water and soluble in organic solvents. It is commonly used in research and development as a building block for the synthesis of pharmaceuticals and other organic compounds. Additionally, it has potential applications in the field of medicinal chemistry due to its structural similarity to certain pharmacologically active molecules. Its properties and potential uses make it a compound of interest for further study and application in various scientific and industrial fields.

InChI:InChI=1/C10H10N2O/c13-7-9-1-3-10(4-2-9)12-6-5-11-8-12/h1-6,8,13H,7H2

Upstream product

• 86718-07-2 ethyl 4-(imidazol-1-yl)benzoate 
• 288-32-4 1H-imidazole 
• 873-75-6 4-bromobenzenemethanol 
• 10040-98-9 1-(4-formylphenyl)-1H-imidazole 
• 18282-51-4 4-iodo-benzyl alcohol 
• 101184-08-1 4-(1H-imidazol-1-yl)benzoic acid methyl ester 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 789445-30-3 1-(4-(chloromethyl) phenyl)-1H-imidazole 
• 86718-09-4 1-[4-(chloro-methyl)phenyl]-1H-imidazole hydrochloride 
• 139277-63-7 3-(4-Imidazol-1-yl-phenyl)-propionic acid hydrazide 
• 143426-74-8 3-(4-Imidazol-1-yl-phenyl)-propionic acid ethyl ester 
• 143426-66-8 ethyl 4-(1-imidazolyl)phenylacetate 
• 139277-59-1 (4-Imidazol-1-yl-phenyl)-acetic acid hydrazide 
• 74002-94-1 (E)-3-(4-Imidazol-1-yl-phenyl)-acrylic acid ethyl ester 
• 1000543-86-1 (4-Imidazol-1-yl-phenyl)-acetic acid 
• 143426-57-7 (4-Imidazol-1-yl-phenyl)-acetonitrile 
• 1266193-16-1 4-(1H-imidazol-1-yl)phenylmethyl bromide hydrobromide 
• 10040-98-9 1-(4-formylphenyl)-1H-imidazole 

Relevant articles and documents

Copper(I) Oxide/N,N′-Bis[(2-furyl)methyl]oxalamide-Catalyzed Coupling of (Hetero)aryl Halides and Nitrogen Heterocycles at Low Catalytic Loading

An easily prepared oxalic diamide is a powerful ligand for the copper-catalyzed coupling of aryl halides with nitrogen heterocycles. Only 1–2 mol% each of copper(I) oxide and N,N′-bis[(2-furyl)methyl]oxalamide (BFMO) are needed to form N-arylation products under mild conditions. More than 10 different types of nitrogen heterocycles are compatible with these conditions, thereby giving the corresponding N-arylation products. (Figure presented.).

A highly efficient Cu-catalyst system for N-arylation of azoles in water

6,7-Dihydroquinolin-8(5H)-one oxime (L3) was found to serve as a superior ligand for the CuI-catalyzed N-arylation of imidazoles with aryl iodides, bromides, and electron-deficient chlorides in water. Moreover, the CuI/L3 catalyst system enabled the coupling reactions to take place smoothly with high yields under a low catalyst loading (0.1-1 mol% CuI and 0.2-2 mol% L3).

Highly functional group tolerance in copper-catalyzed N-arylation of nitrogen-containing heterocycles under mild conditions

A copper-catalyzed process has been developed for the N-arylation reaction under very mild conditions in the absence of additional ligand. This protocol could not only tolerate an array of thermally sensitive functional groups, but also achieve high chemoselectivity.