(-)-1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane

Base Information

• Chemical Name: (-)-1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane
• CAS No.: 43061-13-8
• Molecular Formula: C12H19NO2
• Molecular Weight: 209.288
• UNII: LX3MC6OB9X
• ChEMBL ID: CHEMBL317634
• DSSTox Substance ID: DTXSID50110007
• Nikkaji Number: J400.393D
• Wikidata: Q209257
• Mol file: 43061-13-8.mol

Synonyms:43061-13-8;LX3MC6OB9X;(-)-Dom;(R)-2,5-Dimethoxy-4-methylamphetamine;(-)-1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane;UNII-LX3MC6OB9X;2,5-Dimethoxy-4-methylamphetamine, (R)-;CHEMBL317634;(R)-(-)-2,5-Dimethoxy-4-methylamphetamine;Benzeneethanamine, 2,5-dimethoxy-alpha,4-dimethyl-, (alphaR)-;SCHEMBL1742173;DOM, (R)-;DTXSID50110007;BDBM50367392;PDSP2_000453;r-2,5-dimethoxy-4-methylamphetamine;NS00070002;Q209257;BENZENEETHANAMINE, 2,5-DIMETHOXY-.ALPHA.,4-DIMETHYL-, (.ALPHA.R)-

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Chemical Property of (-)-1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane

Chemical Property:

• PSA: 44.48000
• LogP: 2.60220
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 209.141578849
• Heavy Atom Count: 15
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1OC)CC(C)N)OC
• Isomeric SMILES: CC1=CC(=C(C=C1OC)C[C@@H](C)N)OC

Technology Process of (-)-1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane

There total 12 articles about (-)-1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(R)-2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethyl]-((R)-1-phenyl-ethyl)-amine; hydrochloride → (-)-DOM (43061-13-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water;

DOI:10.1021/jm00263a013

Reference yield:

(2R)-1-(2,5-dimethoxy-4-methylphenyl)-2-propyl azide → (-)-DOM (43061-13-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 12h; under 2068.59 Torr;

DOI:10.1016/S0957-4166(03)00438-5

Reference yield:

(2S)-1-(2,5-dimethoxy-4-methylphenyl)-2-propyl azide (609771-68-8) → (+)-DOM (43061-14-9) + (-)-DOM (43061-13-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 2068.59 Torr; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(03)00438-5

upstream raw materials:

1-(2,5-Dimethoxy-4-methyl-phenyl)-2-nitro-propen

(2S)-1-(2,5-dimethoxy-4-methylphenyl)-2-propyl azide

2,5-dimethoxy toluene

1-bromo-2,5-dimethoxy-4-methylbenzene

Downstream raw materials:

(R)-1-(2,5-dimethoxy-4-methylphenyl)-2-<(benzoyloxy)amino>propane

(R)-1-(2,5-dimethoxy-4-methylphenyl)-2-(hydroxyamino)propane hydrochloride