(4R,5R)-4,5-diMethyl-L-Proline ethyl ester

Base Information

• Chemical Name: (4R,5R)-4,5-diMethyl-L-Proline ethyl ester
• CAS No.: 147512-07-0
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.239
• Mol file: 147512-07-0.mol

Synonyms:(4R,5R)-4,5-diMethyl-L-Proline ethyl ester

Chemical Property of (4R,5R)-4,5-diMethyl-L-Proline ethyl ester

Chemical Property:

Purity/Quality:

(4R,5R)-4,5-dimethyl-L-Prolineethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-4,5-diMethyl-L-Proline ethyl ester

There total 4 articles about (4R,5R)-4,5-diMethyl-L-Proline ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

ethanol (64-17-5) + (2R,6R,8S,12S)-1-aza-10-oxo-12-phenyl-4-thiatricyclo<6.4.01,8.02,6>dodecan-9-one (147406-87-9) → (2S,4R,5R)-4,5-dimethylproline ethyl ester (147512-07-0)

Guidance literature:

With W-4 Raney nickel; for 12h; Heating;

DOI:10.1016/0040-4039(93)85121-C

Reference yield:

allyl 2-hydroxyethyl sulfide (58965-04-1) → (2S,4R,5R)-4,5-dimethylproline ethyl ester (147512-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / PCC / CH₂Cl₂

2: 75 percent / molecular sieves / toluene / 48 h / Heating

3: 15 percent / W-4 Raney nickel / 12 h / Heating

With molecular sieve; W-4 Raney nickel; pyridinium chlorochromate; In dichloromethane; toluene;

DOI:10.1016/0040-4039(93)85121-C

Reference yield:

2‐(prop‐2‐en‐1‐ylsulfanyl)-acetaldehyde (120983-16-6) → (2S,4R,5R)-4,5-dimethylproline ethyl ester (147512-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / molecular sieves / toluene / 48 h / Heating

2: 15 percent / W-4 Raney nickel / 12 h / Heating

With molecular sieve; W-4 Raney nickel; In toluene;

DOI:10.1016/0040-4039(93)85121-C

upstream raw materials:

ethanol

(2R,6R,8S,12S)-1-aza-10-oxo-12-phenyl-4-thiatricyclo<6.4.0^1,8.0^2,6>dodecan-9-one

allyl 2-hydroxyethyl sulfide

2‐(prop‐2‐en‐1‐ylsulfanyl)-acetaldehyde

Refernces