1-(4-CHLORO-2-FLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE

Base Information

• Chemical Name: 1-(4-CHLORO-2-FLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE
• CAS No.: 886370-99-6
• Molecular Formula: C8H3ClF4O
• Molecular Weight: 226.558
• Mol file: 886370-99-6.mol

Synonyms:4'-CHLORO-2'-FLUORO-2,2,2-TRIFLUOROACETOPHENONE;4-CHLORO-2-FLUORO TRIFLUORO ACETOPHENONE;1-(4-CHLORO-2-FLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE

Chemical Property of 1-(4-CHLORO-2-FLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE

Chemical Property:

• Vapor Pressure: 0.157mmHg at 25°C
• Boiling Point: 214.3°C at 760 mmHg
• Flash Point: 83.4°C
• PSA: 17.07000
• Density: 1.475g/cm³
• LogP: 3.22410

Purity/Quality:

99%min ^*data from raw suppliers

4'-Chloro-2'-fluoro-2,2,2-trifluoroacetophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-CHLORO-2-FLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE

There total 2 articles about 1-(4-CHLORO-2-FLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl trifluoroacetate, (383-63-1) + 4-chloro-2-fluoro-1-iodobenzene (6797-79-1) → 1-(4-chloro-2-fluoro-phenyl)-2,2,2-trifluoro-ethanone (886370-99-6)

Guidance literature:

4-chloro-2-fluoro-1-iodobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

ethyl trifluoroacetate,; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield:

trifluoroacetic acid-methyl ester (431-47-0) + 4-chloro-2-fluoro-1-iodobenzene (6797-79-1) → 1-(4-chloro-2-fluoro-phenyl)-2,2,2-trifluoro-ethanone (886370-99-6)

Guidance literature:

4-chloro-2-fluoro-1-iodobenzene; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 1h; Inert atmosphere;

trifluoroacetic acid-methyl ester; In tetrahydrofuran; hexanes; at -78 - 20 ℃;

upstream raw materials:

ethyl trifluoroacetate,

4-chloro-2-fluoro-1-iodobenzene

trifluoroacetic acid-methyl ester

Refernces

• 1、 -. "OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS". Page/Page column 31; 32. . Retrieved 2012/04/05.