(R)-1-Amino-3-morpholinopropan-2-ol

Base Information

• Chemical Name: (R)-1-Amino-3-morpholinopropan-2-ol
• CAS No.: 452105-38-3
• Molecular Formula: C₇H₁₆N₂O₂
• Molecular Weight: 160.216
• Hs Code.: 2934999090
• European Community (EC) Number: 695-210-8
• Wikidata: Q76139503
• Mol file: 452105-38-3.mol

Synonyms:452105-38-3;(R)-1-Amino-3-morpholinopropan-2-ol;(2R)-1-amino-3-(morpholin-4-yl)propan-2-ol;(2R)-1-amino-3-morpholin-4-ylpropan-2-ol;SCHEMBL2779513;MFCD09787505;AKOS026729464;CS-0231204;(R)-1-Amino-3-(4-morpholinyl)-2-propanol;(R)-1-Amino-3-morpholin-4-yl-propan-2-ol;EN300-107395;4-[(2R)-3-Amino-2-hydroxyprop-1-yl]morpholine;Z1255399817;4-Morpholineethanol,alpha-(aminomethyl)-,(alphaR)-(9CI)

Chemical Property of (R)-1-Amino-3-morpholinopropan-2-ol

Chemical Property:

• Boiling Point: 286.4±29.0 °C(Predicted)
• PKA: 12.56±0.35(Predicted)
• PSA: 58.72000
• Density: 1.111±0.06 g/cm3(Predicted)
• LogP: -0.72360
• XLogP3: -1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 160.121177757
• Heavy Atom Count: 11
• Complexity: 105

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-Amino-3-morpholinopropan-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CC(CN)O
• Isomeric SMILES: C1COCCN1C[C@@H](CN)O

Technology Process of (R)-1-Amino-3-morpholinopropan-2-ol

There total 3 articles about (R)-1-Amino-3-morpholinopropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(2R)-(+)-N-(2,3-epoxypropyl)morpholine (141395-84-8) → (R)-1-Amino-3-(4-morpholinyl)-2-propanol (452105-38-3)

Guidance literature:

With ammonia; In water; at 0 - 20 ℃;

Reference yield: 70.0%

(S)-1-Azido-3-morpholin-4-yl-propan-2-ol (141395-85-9) → (R)-1-Amino-3-(4-morpholinyl)-2-propanol (452105-38-3)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol;

DOI:10.1016/S0040-4039(00)91716-7

Reference yield:

→ (R)-1-Amino-3-(4-morpholinyl)-2-propanol (452105-38-3)

Guidance literature:

upstream raw materials:

(S)-1-Azido-3-morpholin-4-yl-propan-2-ol

(2R)-(+)-N-(2,3-epoxypropyl)morpholine

Downstream raw materials:

(S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

[(S)-1-((2R,8S,11S,12R)-11-Cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

(4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{(R)-1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-2-morpholin-4-yl-ethyl} ester 3-tert-butyl ester

((2R,8S,11S,12R)-11-Cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-carbamic acid benzyl ester

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