(S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

Base Information

Chemical Name:(S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide
CAS No.:135970-78-4
Molecular Formula:C₃₆H₅₆N₄O₉S
Molecular Weight:720.928
Hs Code.:

(S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

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Chemical Property of (S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

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Technology Process of (S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

There total 12 articles about (S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6270-19-5
4-(oxiran-2-ylmethyl)morpholine

: 135970-78-4
(S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

Guidance literature:: Multi-step reaction with 8 steps

1: LiN₃ / dimethylformamide

2: H₂ / Pd(OH)2 / methanol

3: EDC, HOBt / CH₂Cl₂

4: 37 percent / EDC, DMAP / CH₂Cl₂

5: TFA / CH₂Cl₂

6: EDC, DMAP*HCl / CHCl₃; tetrahydrofuran / Heating

7: H₂ / Pd-C / ethyl acetate; tetrahydrofuran; methanol

8: EDC, HOBt, NMM / CH₂Cl₂

With 4-methyl-morpholine; dmap; lithium azide; hydrogen; 4-(dimethylamino)pyridine hydrochloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)91716-7

Reference yield:

: 121909-82-8
1-azido-2-hydroxy-3-morpholinopropane

: 135970-78-4
(S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd(OH)2 / methanol

2: EDC, HOBt / CH₂Cl₂

3: 37 percent / EDC, DMAP / CH₂Cl₂

4: TFA / CH₂Cl₂

5: EDC, DMAP*HCl / CHCl₃; tetrahydrofuran / Heating

6: H₂ / Pd-C / ethyl acetate; tetrahydrofuran; methanol

7: EDC, HOBt, NMM / CH₂Cl₂

With 4-methyl-morpholine; dmap; hydrogen; 4-(dimethylamino)pyridine hydrochloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate;
DOI:10.1016/S0040-4039(00)91716-7

Reference yield:

: (2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyric acid (S)-1-[((S)-4-benzyloxycarbonylamino-4-carboxy-butyrylamino)-methyl]-2-morpholin-4-yl-ethyl ester

: 135970-78-4
(S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: EDC, DMAP*HCl / CHCl₃; tetrahydrofuran / Heating

2: H₂ / Pd-C / ethyl acetate; tetrahydrofuran; methanol

3: EDC, HOBt, NMM / CH₂Cl₂

With 4-methyl-morpholine; hydrogen; 4-(dimethylamino)pyridine hydrochloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate;
DOI:10.1016/S0040-4039(00)91716-7