(R)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl) butanoate .(R)-2-hydroxy-2-phenylacetate

Base Information

• Chemical Name: (R)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl) butanoate .(R)-2-hydroxy-2-phenylacetate
• CAS No.: 1253055-94-5
• Molecular Formula: C19H20F3NO5
• Molecular Weight: 399.367
• Mol file: 1253055-94-5.mol

Synonyms:(R)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl) butanoate .(R)-2-hydroxy-2-phenylacetate

Chemical Property of (R)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl) butanoate .(R)-2-hydroxy-2-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl) butanoate .(R)-2-hydroxy-2-phenylacetate

There total 4 articles about (R)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl) butanoate .(R)-2-hydroxy-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate (1253055-92-3) + (R)-Mandelic Acid (611-71-2) → (R)-(-)-mandelic acid salt of (R)-methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate (1253055-94-5)

Guidance literature:

In isopropyl alcohol; at 25 - 30 ℃;

Reference yield:

(2,4,5-trifluorophenyl)acetic acid (209995-38-0) → (R)-(-)-mandelic acid salt of (R)-methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate (1253055-94-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 25 - 30 °C

1.2: 6 h / 50 - 55 °C

2.1: 60 - 63 °C

3.1: ammonium acetate / methanol / 60 - 63 °C

4.1: sulfuric acid / methanol / -10 - 0 °C

4.2: 2 h / -10 - 0 °C

4.3: pH 8 - 9

5.1: isopropyl alcohol / 3 h / 25 - 30 °C

With sulfuric acid; ammonium acetate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; isopropyl alcohol;

Reference yield:

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (764667-64-3) → (R)-(-)-mandelic acid salt of (R)-methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate (1253055-94-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 60 - 63 °C

2.1: ammonium acetate / methanol / 60 - 63 °C

3.1: sulfuric acid / methanol / -10 - 0 °C

3.2: 2 h / -10 - 0 °C

3.3: pH 8 - 9

4.1: isopropyl alcohol / 3 h / 25 - 30 °C

With sulfuric acid; ammonium acetate; In methanol; isopropyl alcohol;

upstream raw materials:

methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate

(R)-Mandelic Acid

(2,4,5-trifluorophenyl)acetic acid

5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Downstream raw materials:

3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

sitagliptin

(R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate