Dihydro-5,5-dimethylthiopyran-3(4H)-one

Base Information

• Chemical Name: Dihydro-5,5-dimethylthiopyran-3(4H)-one
• CAS No.: 18615-62-8
• Molecular Formula: C₇H₁₂OS
• Molecular Weight: 144.238
• Hs Code.: 2934999090
• Mol file: 18615-62-8.mol

Synonyms:Dihydro-5,5-dimethylthiopyran-3(4H)-one;5,5-diMethyldihydrothiopyran-3-one

Chemical Property of Dihydro-5,5-dimethylthiopyran-3(4H)-one

Chemical Property:

• PSA: 42.37000
• LogP: 1.71860

Purity/Quality:

98%min ^*data from raw suppliers

Dihydro-5,5-dimethylthiopyran-3(4H)-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dihydro-5,5-dimethylthiopyran-3(4H)-one

There total 2 articles about Dihydro-5,5-dimethylthiopyran-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-(2-chloroallylsulfanyl)-2-methylpropan-2-ol (1049093-42-6) → 5,5-dimethyl-dihydro-thiopyran-3-one (18615-62-8)

Guidance literature:

With formic acid; for 4h; Heating / reflux;

Reference yield:

→ 5,5-dimethyl-dihydro-thiopyran-3-one (18615-62-8)

Guidance literature:

Entspr. Carbinol, H2SO4;

DOI:10.1021/ja00722a018

Reference yield: 68.0%

5,5-dimethyl-dihydro-thiopyran-3-one (18615-62-8) → C7H12O3S (1049093-43-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 4h;

upstream raw materials:

1-(2-chloroallylsulfanyl)-2-methylpropan-2-ol

Downstream raw materials:

C₇H₁₂O₂S

C₇H₁₂O₃S

C₁₃H₁₈N₂O₂S

C₁₃H₁₈N₂O₃S

Refernces

• 1、 Vandyck, Koen,Cummings, Maxwell D.,Nyanguile, Origène,Boutton, Carlo W.,Vendeville, Sandrine,McGowan, David,Devogelaere, Benoit,Amssoms, Katie,Last, Stefaan,Rombauts, Klara,Tahri, Abdellah,Lory, Pedro,Hu, Lili,Beauchamp, Derek A.,Simmen, Kenny,Raboisson, Pierre. "Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase". scheme or table. p. 4099 - 4102. Retrieved 2010/02/28.