5-(4-Fluorophenyl)-3-nitro-2-pyridinylamine

Base Information

• Chemical Name: 5-(4-Fluorophenyl)-3-nitro-2-pyridinylamine
• CAS No.: 640271-51-8
• Molecular Formula: C11H8FN3O2
• Molecular Weight: 233.202
• Hs Code.: 2933399990
• Mol file: 640271-51-8.mol

Synonyms:5-(4-Fluorophenyl)-3-nitro-2-pyridinylamine

Chemical Property of 5-(4-Fluorophenyl)-3-nitro-2-pyridinylamine

Chemical Property:

• PSA: 84.73000
• LogP: 3.48250
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-(4-Fluorophenyl)-3-nitro-2-pyridinylamine >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-Fluorophenyl)-3-nitro-2-pyridinylamine

There total 1 articles about 5-(4-Fluorophenyl)-3-nitro-2-pyridinylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-fluoroboronic acid (1765-93-1) + 5-bromo-3-nitro-pyridin-2-ylamine (6945-68-2) → 5-(4-Fluorophenyl)-3-nitropyridin-2-amine (640271-51-8)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 9h;

Reference yield: 89.0%

5-(4-Fluorophenyl)-3-nitropyridin-2-amine (640271-51-8) + di-tert-butyl dicarbonate (24424-99-5) → Bis-tert-Butyl (5-(4-fluorophenyl)-3-nitropyridin-2-yl)carbamate

Guidance literature:

With dmap; In tetrahydrofuran; for 0.5h;

Reference yield:

5-(4-Fluorophenyl)-3-nitropyridin-2-amine (640271-51-8) → 6-(4-fluorophenyl)-1-[(1-methylpyrazol-4-yl)methyl]-3H-imidazo[4,5-b]pyridin-2-one

Guidance literature:

Multi-step reaction with 5 steps

1.1: dmap / tetrahydrofuran / 0.5 h

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 3 h / 760.05 Torr

3.1: acetic acid / trans-1,2-dichloroethylene

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.1: tetrahydrofuran / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; acetic acid; trifluoroacetic acid; In tetrahydrofuran; trans-1,2-dichloroethylene; ethanol; dichloromethane;

upstream raw materials:

4-fluoroboronic acid

5-bromo-3-nitro-pyridin-2-ylamine

Refernces

• 1、 -. "AMINOPYRIDINE-DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS". Page/Page column 46. . Retrieved 2010/02/12.