ONC201,TIC10

Base Information

Chemical Name:ONC201,TIC10
CAS No.:1616632-77-9
Molecular Formula:C24H26N4O
Molecular Weight:386.497
Hs Code.:
Mol file:1616632-77-9.mol

Synonyms:ONC201,TIC10;TIC-10 (ON201);2,4,6,7,8,9-Hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one;TIC10(ONC-201);TIC 10 active isomer

Suppliers and Price of ONC201,TIC10

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one
50mg
$ 160.00

DC Chemicals
TIC10 >98%
1 g
$ 1400.00

DC Chemicals
TIC10 >98%
100 mg
$ 350.00

Crysdot
TIC10(ONC-201) 98+%
50mg
$ 240.00

Crysdot
TIC10(ONC-201) 98+%
250mg
$ 520.00

Crysdot
TIC10(ONC-201) 98+%
100mg
$ 360.00

Cayman Chemical
TIC10 ≥98%
1mg
$ 25.00

Cayman Chemical
TIC10 ≥98%
5mg
$ 88.00

Cayman Chemical
TIC10 ≥98%
10mg
$ 163.00

Cayman Chemical
TIC10 ≥98%
25mg
$ 344.00

Total 20 raw suppliers

Chemical Property of ONC201,TIC10

Chemical Property:

Boiling Point:559.7±60.0 °C(Predicted)
PKA:6.38±0.20(Predicted)
PSA：42.53000
Density:1.24±0.1 g/cm3(Predicted)
LogP:1.85260
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
Solubility.:Soluble in DMSO (up to 25 mg/ml with warming).

Purity/Quality:

99%, ^*data from raw suppliers

7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 μM in a p53-independent manner. It is orally active, stable, and crosses the blood-brain barrier. The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a. TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.

Technology Process of ONC201,TIC10

There total 9 articles about ONC201,TIC10 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 38941-29-6
N-(2-methylbenzyl)-4,5-dihydro-1H-imidazol-2-amine

: 3939-01-3
methyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

: 1616632-77-9
11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetraazatricyclo[7.4.0.0^2,6]trideca-1⁽⁹⁾,5-dien-8-one

Guidance literature:: With sodium methylate; In methanol; for 18h; Inert atmosphere;
DOI:10.1002/anie.201402133

Reference yield: 52.0%

: 4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one

: 100-39-0
benzyl bromide

: 1616632-77-9
11-benzyl-7-[(2-methylphenyl)methyl]-2,5,7,11-tetraazatricyclo[7.4.0.0^2,6]trideca-1⁽⁹⁾,5-dien-8-one

Guidance literature:: 4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1039/d1ob01561c