4-methyl-N-(4-nitrophenyl)-1-Piperazineacetamide

Base Information

Chemical Name:4-methyl-N-(4-nitrophenyl)-1-Piperazineacetamide
CAS No.:708279-23-6
Molecular Formula:C₁₃H₁₈N₄O₃
Molecular Weight:278.311
Hs Code.:
Mol file:708279-23-6.mol

Synonyms:4-methyl-N-(4-nitrophenyl)-1-Piperazineacetamide

Suppliers and Price of 4-methyl-N-(4-nitrophenyl)-1-Piperazineacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 4-methyl-N-(4-nitrophenyl)-1-Piperazineacetamide

Chemical Property:

Purity/Quality:: 95%+HPLC ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-Methyl-N-(4-nitrophenyl)-1-piperazineacetamide is an intermediate in the synthesis of Desmethyl Nintedanib (D422370), an impurity of Intedanib (I666650), which is an antitumor agent. Desmethyl Nintedanib was used in the study of synthesizing indolinones as triple angiokinase inhibitors.

Technology Process of 4-methyl-N-(4-nitrophenyl)-1-Piperazineacetamide

There total 3 articles about 4-methyl-N-(4-nitrophenyl)-1-Piperazineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 109-01-3
1-methyl-piperazine

: 17329-87-2
2-chloro-N-(4-nitro-phenyl)-acetamide

: 708279-23-6
2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide

Guidance literature:: In isopropyl alcohol; at 80 ℃; for 17h; Inert atmosphere;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 3598-91-2
N-(4-nitrophenyl)bromoacetamide

: 708279-23-6
2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 3h;
DOI:10.1021/jm900431g

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 708279-23-6
2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

2: isopropyl alcohol / 17 h / 80 °C / Inert atmosphere

With triethylamine; In tetrahydrofuran; isopropyl alcohol;