1-Piperazinecarboxylic acid,4-[(5-amino-2-chlorophenyl)methyl]-,1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperazinecarboxylic acid,4-[(5-amino-2-chlorophenyl)methyl]-,1,1-dimethylethyl ester
• CAS No.: 769961-14-0
• Molecular Formula: C16H24ClN3O2
• Molecular Weight: 325.838

Synonyms:1-Piperazinecarboxylic acid,4-[(5-amino-2-chlorophenyl)methyl]-,1,1-dimethylethyl ester

Chemical Property of 1-Piperazinecarboxylic acid,4-[(5-amino-2-chlorophenyl)methyl]-,1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 442.2±45.0 °C(Predicted)
• PSA: 58.80000
• Density: 1.214±0.06 g/cm3(Predicted)
• LogP: 3.43190

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-Piperazinecarboxylic acid,4-[(5-amino-2-chlorophenyl)methyl]-,1,1-dimethylethyl ester

There total 4 articles about 1-Piperazinecarboxylic acid,4-[(5-amino-2-chlorophenyl)methyl]-,1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

tert-butyl 4-(2-chloro-5-nitrobenzyl)piperazine-1-carboxylate (1150308-67-0) → tert-butyl 4-(5-amino-2-chlorobenzyl)piperazine-1-carboxylate (769961-14-0)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; for 1h; Reflux;

Reference yield:

2-chloro-5-nitrobenzaldehyde (6361-21-3) → tert-butyl 4-(5-amino-2-chlorobenzyl)piperazine-1-carboxylate (769961-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 0 - 20 °C

2: iron; hydrogenchloride / water; ethanol / 1 h / Reflux

With hydrogenchloride; sodium tris(acetoxy)borohydride; iron; In ethanol; dichloromethane; water;

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(5-amino-2-chlorobenzyl)piperazine-1-carboxylate (769961-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 0 - 20 °C

2: iron; hydrogenchloride / water; ethanol / 1 h / Reflux

With hydrogenchloride; sodium tris(acetoxy)borohydride; iron; In ethanol; dichloromethane; water;

upstream raw materials:

2-chloro-5-nitrobenzaldehyde

tert-butyl 4-(2-chloro-5-nitrobenzyl)piperazine-1-carboxylate

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

tert-butyl 4-(5-((5-amino-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate

tert-butyl 4-(5-((5-(4-aminothieno[3,2-d]pyrimidine-7-carboxamido)-6-methylisoquinolin-1-yl)amino)-2-chlorobenzyl)piperazine-1-carboxylate

4-amino-N-(1-((4-chloro-3-(piperazin-1-ylmethyl)phenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide hydrochloride

tert-butyl 4-(2-chloro-5-((6-methyl-5-nitroisoquinolin-1-yl)amino)benzyl)piperazine-1-carboxylate

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