Technology Process of Chondrocurine
There total 41 articles about Chondrocurine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium carbonate / ethanol / 5 h
2: sodium tetrahydroborate / ethanol / 20 °C
3: phosphorus tribromide / 0 - 20 °C
4: sodium tetrahydroborate; potassium hexamethylsilazane / methanol
5: pyridine; caesium carbonate; copper(I) bromide dimethylsulfide complex / 36.25 h / 20 - 135 °C / Molecular sieve; Inert atmosphere; Sealed tube
6: pyridine; caesium carbonate; copper(I) bromide dimethylsulfide complex / 288 h / 20 - 130 °C / Molecular sieve; Inert atmosphere; Sealed tube
7: boron tribromide / hexane; dichloromethane / 2 h / -19 °C
With
pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; boron tribromide; phosphorus tribromide; potassium hexamethylsilazane; potassium carbonate; caesium carbonate;
In
methanol; ethanol; hexane; dichloromethane;
6: |Ullmann Condensation;
DOI:10.1021/acs.joc.6b02647
- Guidance literature:
-
With
boron tribromide;
In
hexane; dichloromethane;
at -19 ℃;
for 2h;
Overall yield = 72 %; Overall yield = 6.2 mg;
DOI:10.1021/acs.joc.6b02647
- Guidance literature:
-
Multi-step reaction with 10 steps
1: bromine; acetic acid / 18 h / 0 - 20 °C
2: potassium carbonate / ethanol / 80 °C
3: borane-THF / tetrahydrofuran / 15 h / 20 °C
4: 42 h / 40 °C
5: potassium acetate; iodine / ethanol / 0.5 h / 20 °C
6: methanol / 20 °C
7: sodium tetrahydroborate; potassium hexamethylsilazane / methanol
8: pyridine; caesium carbonate; copper(I) bromide dimethylsulfide complex / 36.25 h / 20 - 135 °C / Molecular sieve; Inert atmosphere; Sealed tube
9: pyridine; caesium carbonate; copper(I) bromide dimethylsulfide complex / 288 h / 20 - 130 °C / Molecular sieve; Inert atmosphere; Sealed tube
10: boron tribromide / hexane; dichloromethane / 2 h / -19 °C
With
pyridine; sodium tetrahydroborate; borane-THF; copper(I) bromide dimethylsulfide complex; bromine; iodine; potassium acetate; boron tribromide; potassium hexamethylsilazane; potassium carbonate; caesium carbonate; acetic acid;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;
9: |Ullmann Condensation;
DOI:10.1021/acs.joc.6b02647
