tert-Butyl 4-(3-methylpyridin-2-yl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-(3-methylpyridin-2-yl)piperazine-1-carboxylate
• CAS No.: 946386-15-8
• Molecular Formula: C15H23N3O2
• Molecular Weight: 277.36
• Mol file: 946386-15-8.mol

Synonyms:tert-Butyl 4-(3-methylpyridin-2-yl)piperazine-1-carboxylate

Chemical Property of tert-Butyl 4-(3-methylpyridin-2-yl)piperazine-1-carboxylate

Chemical Property:

• PSA: 45.67000
• LogP: 2.45000

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl4-(3-Methylpyridin-2-yl)piperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of tert-Butyl 4-(3-methylpyridin-2-yl)piperazine-1-carboxylate

There total 2 articles about tert-Butyl 4-(3-methylpyridin-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-chloro-2-picoline (18368-63-3) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(3-methyl-2-pyridyl)piperazine-1-carboxylate (946386-15-8)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 20 - 100 ℃; for 2h;

Reference yield:

2-bromo-3-picoline (3430-17-9) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(3-methyl-2-pyridyl)piperazine-1-carboxylate (946386-15-8)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 5h; Inert atmosphere;

Reference yield: 98.0%

tert-butyl 4-(3-methyl-2-pyridyl)piperazine-1-carboxylate (946386-15-8) → 1-(3-methyl-2-pyridinyl)piperazine dihydrochloride (111960-11-3,2007909-71-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 3h; Inert atmosphere;

upstream raw materials:

2-bromo-3-picoline

1-t-Butoxycarbonylpiperazine

6-chloro-2-picoline

Downstream raw materials:

1-(3-methylpyridin-2-yl)piperazine dihydrochloride salt

1-(3-methyl-2-pyridinyl)piperazine dihydrochloride

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