18368-63-3

Basic information

• Product Name: 6-Chloro-2-picoline
• Synonyms: 2-Chloro-6-Pilcoline;C234;6-CHLORO-2-METHYLPYRIDINE;6-CHLORO-2-PICOLINE;2-CHLORO-6-METHYLPYRIDINE;2-CHLORO-6-PICOLINE;2-Picoline, 6-chloro-;Pyridine, 2-chloro-6-methyl-
• CAS NO: 18368-63-3
• Molecular Formula: C₆H₆ClN
• Molecular Weight: 127.57
• EINECS: 242-241-6
• Product Categories: Pyridine;pyridine derivative;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Boronic Acid;pyridine series;Building Blocks;C6;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyridine series;alkyl chloride
• Mol File: 18368-63-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 64-68 °C10 mm Hg(lit.)
• Flash Point: 165 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.167 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.05mmHg at 25°C
• Refractive Index: n20/D 1.527(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.10±0.10(Predicted)
• BRN: 107187
• CAS DataBase Reference: 6-Chloro-2-picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-2-picoline(18368-63-3)
• EPA Substance Registry System: 6-Chloro-2-picoline(18368-63-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• RIDADR: UN2810
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 18368-63-3(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow liquid

Uses

2-Chloro-6-methylpyridine has been used for experimental FTIR and FT-Raman spectroscopic analyses, as well as for conformational studies.

InChI:InChI=1/C6H6ClN/c1-5-3-2-4-6(7)8-5/h2-4H,1H3

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 3279-76-3 6-hydroxy-2-methylpyridine 
• 63071-03-4 2-methoxy-6-methyl-pyridine 
• 107622-87-7 2-benzyloxy-6-methylpyridine 
• 109-09-1 2-chloropyridine 
• 17200-12-3 lithium 2-(dimethylamino)ethanolate 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 934-60-1 6-methyl-2-pyridinecarboxylic acid 
• 109-06-8 α-picoline 
• 1984-23-2 p-nitrophenyl isocyanide 
• 931-19-1 2-methylpyridine N-oxide 
• 10025-87-3 trichlorophosphate 

Downstream Products

• 28369-92-8 2-methyl-6-phenoxypyridine 
• 407-22-7 2-fluoro-6-methylpyridine 
• 52313-59-4 2-Chloro-6-methylpyridine N-oxide 
• 113577-68-7 2-(2-methoxyphenyl)-6-methylpyridine 
• 46181-30-0 6-methyl-2-phenylpyridine 
• 63763-79-1 2-chloro-6-(bromomethyl)pyridine 
• 132682-77-0 diphenyl-(6-methyl-pyridin-2-yl)phosphine 
• 63071-04-5 2-methoxy-6-methylpyridine 
• 5315-25-3 2-bromo-6-methylpyridine 
• 62674-71-9 2-iodo-6-methyl-pyridine 
• 460079-58-7 2-(6-chloro-2-pyridinyl)-1-(3-methylphenyl)ethanone 
• 460079-42-9 1-(3-bromophenyl)-2-(6-chloro-2-pyridinyl)ethanone 
• 437384-15-1 2-(6-chloro-2-pyridinyl)-1-(4-methoxyphenyl)ethanone 
• 460079-84-9 2-(6-chloro-2-pyridinyl)-1-(3-methoxyphenyl)ethanone 

Relevant articles and documents

Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions

A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.

Unusual C-6 lithiation of 2-chloropyridine-mediated by BuLi-Me2N(CH2)2OLi. New access to 6-functional-2-chloropyridines and chloro-bis-heterocycles

Formula Presented The reaction of 2-chloropyridine with alkylithium generally results in nucleophilic addition leading to the loss of chlorine atom while exclusive directed ortho metalation is obtained using LDA. Herein it is shown that the BuLi-Me2

Pyridylthio-acylanilide herbicides

Novel herbicidally active pyridylthio-acylanilides of the formula STR1 in which R1, R2 and R3, independently of one another, represent hydrogen, halogen, cyano or trifluoromethyl or alkyl, alkoxy and alkylthio having 1 to 4 carbon atoms in each case, R4 represents halogen, methyl or methoxy, n represents a number 0, 1 or 2, z represents the group (Ia) STR2 or the group (Ib) STR3 where X represents oxygen, sulphur, an N--R10 or N--O--R11 group, or X and Rg tpgether represent the STR4 radical, and the other radicals can have various meanings. Intermediates of the formulae STR5 are also new.