tert-Butyl azetidine-3-carboxylate acetate

Base Information

• Chemical Name: tert-Butyl azetidine-3-carboxylate acetate
• CAS No.: 1236144-52-7
• Molecular Formula: C8H15NO2
• Molecular Weight: 217.265
• Mol file: 1236144-52-7.mol

Synonyms:tert-Butyl azetidine-3-carboxylate acetate

Chemical Property of tert-Butyl azetidine-3-carboxylate acetate

Chemical Property:

• PSA: 38.33000
• LogP: 0.87630
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

tert-ButylAzetidine-3-carboxylateHOAc ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl azetidine-3-carboxylate acetate

There total 3 articles about tert-Butyl azetidine-3-carboxylate acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

O1-benzyl-O3-tert-butylazetidine-1,3-dicarboxylate (1236144-51-6) + acetic acid (64-19-7,77671-22-8) → tert-butyl azetidine-3-carboxylate acetic acid salt (1236144-52-7)

Guidance literature:

O₁-benzyl-O₃-tert-butylazetidine-1,3-dicarboxylate; With hydrogen; palladium 10% on activated carbon; In ethyl acetate; under 2206.72 Torr; Autoclave;

acetic acid; In ethyl acetate;

Reference yield: 92.0%

tert-butyl azetidine-3-carboxylate (790600-78-1) + acetic acid (64-19-7,77671-22-8) → tert-butyl azetidine-3-carboxylate acetic acid salt (1236144-52-7)

Guidance literature:

at 50 ℃;

Reference yield:

O1-benzyl-O3-tert-butylazetidine-1,3-dicarboxylate (1236144-51-6) → tert-butyl azetidine-3-carboxylate acetic acid salt (1236144-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2206.72 Torr / Autoclave

2: 50 °C

With hydrogen; palladium 10% on activated carbon; In ethyl acetate;

upstream raw materials:

O₁-benzyl-O₃-tert-butylazetidine-1,3-dicarboxylate

acetic acid

tert-butyl azetidine-3-carboxylate

Downstream raw materials:

tert-butyl 1-(4-cyanobenzyl)azetidine-3-carboxylate

4-Cyanobenzyl alcohol

tert-butyl 1-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate

1-((3-(4-(4-chlorophenyl)cyclohexyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid