6-Chloro-5-nitropyridin-2-amine

Base Information

• Chemical Name: 6-Chloro-5-nitropyridin-2-amine
• CAS No.: 84487-03-6
• Molecular Formula: C5H4ClN3O2
• Molecular Weight: 173.559
• DSSTox Substance ID: DTXSID80233475
• Nikkaji Number: J107.344C
• Wikidata: Q83115009
• Mol file: 84487-03-6.mol

Synonyms:6-chloro-5-nitropyridin-2-amine;84487-03-6;6-Amino-2-chloro-3-nitropyridine;2-Pyridinamine, 6-chloro-5-nitro-;2-Amino-6-chloro-5-nitropyridine;Pyridine, 2-amino-6-chloro-5-nitro-;BRN 4802511;2-Chloro-6-amino-3-nitropyridine;MFCD01692500;2-Chloro-3-nitropyridine-6-amine;SCHEMBL11198744;DTXSID80233475;XVJLWPXRQLPUPT-UHFFFAOYSA-N;6-Chloro-5-nitropyridin-2-ylamine;AKOS015998765;DS-18207;SY114337;LS-130219;CS-0063917;FT-0755117;A23606;EN300-132796

Chemical Property of 6-Chloro-5-nitropyridin-2-amine

Chemical Property:

• Vapor Pressure: 2.1E-06mmHg at 25°C
• Melting Point: 188 °C
• Boiling Point: 393.6°Cat760mmHg
• PKA: -1.22±0.37(Predicted)
• Flash Point: 191.9°C
• Density: 1.596g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 172.9992041
• Heavy Atom Count: 11
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

6-chloro-5-nitropyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1[N+](=O)[O-])Cl)N

Technology Process of 6-Chloro-5-nitropyridin-2-amine

There total 2 articles about 6-Chloro-5-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 2-chloro-3-nitropyridin-4-amine (2789-25-5) + 6-amino-2-chloro-3-nitropyridine (84487-03-6)

Guidance literature:

With potassium permanganate; ammonia; at -33 ℃; for 5h;

Reference yield: 34.0%

6-chloropyridin-2-amine (45644-21-1) → 6-amino-2-chloro-3-nitropyridine (84487-03-6)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; for 4h;

Reference yield: 83.0%

6-amino-2-chloro-3-nitropyridine (84487-03-6) + phenylmethanethiol (100-53-8) → 6-(benzylthio)-5-nitropyridin-2-amine

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3.5h;

upstream raw materials:

2-Chloro-3-nitropyridine

6-chloropyridin-2-amine

Downstream raw materials:

6-amino-2-ethylthio-3-nitropyridine