ethyl (3-{[1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyridazin-3-yl]methyl}phenyl)carbamate

Base Information

Chemical Name:ethyl (3-{[1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyridazin-3-yl]methyl}phenyl)carbamate
CAS No.:1314380-58-9
Molecular Formula:C₁₈H₁₉N₅O₃
Molecular Weight:353.381
Hs Code.:

Synonyms:ethyl (3-{[1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyridazin-3-yl]methyl}phenyl)carbamate

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Chemical Property of ethyl (3-{[1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyridazin-3-yl]methyl}phenyl)carbamate

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Technology Process of ethyl (3-{[1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyridazin-3-yl]methyl}phenyl)carbamate

There total 6 articles about ethyl (3-{[1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyridazin-3-yl]methyl}phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314388-85-6
3-(chloromethyl)-1-(1-methyl-1H-pyrazol-4-yl)pyridazin-4(1H)-one

: 1314397-95-9
ethyl [3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate

: 1314380-58-9
ethyl (3-{[1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyridazin-3-yl]methyl}phenyl)carbamate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1314388-88-9
1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyrazine-3-carboxylic acid

: 1314380-58-9
ethyl (3-{[1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyridazin-3-yl]methyl}phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: thionyl chloride / acetonitrile / 3 h / 20 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere

With 4-methyl-morpholine; thionyl chloride; sodium carbonate; isobutyl chloroformate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;

Reference yield:

: 210907-84-9
3-aminophenylboronic acid pinacolate

: 1314380-58-9
ethyl (3-{[1-(1-methyl-1H-pyrazol-4-yl)-4-oxo-1,4-dihydropyridazin-3-yl]methyl}phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere

With sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water;