2-[4-(Benzyloxy)phenyl]benzaldehyde

Base Information

• Chemical Name: 2-[4-(Benzyloxy)phenyl]benzaldehyde
• CAS No.: 893736-26-0
• Molecular Formula: C₂₀H₁₆O₂
• Molecular Weight: 288.346
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID70602439
• Wikidata: Q82499517
• Mol file: 893736-26-0.mol

Synonyms:2-[4-(Benzyloxy)phenyl]benzaldehyde;893736-26-0;4'-(Benzyloxy)[1,1'-biphenyl]-2-carbaldehyde;4'-(Benzyloxy)-[1,1'-biphenyl]-2-carbaldehyde;2-(4-phenylmethoxyphenyl)benzaldehyde;DTXSID70602439;MFCD06802252;AKOS004116197;BS-23906;CS-0208263;F87502;4'-(Benzyloxy)[1,1'-biphenyl]-2-carbaldehyde, AldrichCPR

Chemical Property of 2-[4-(Benzyloxy)phenyl]benzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 4.74510
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 288.115029749
• Heavy Atom Count: 22
• Complexity: 327

Purity/Quality:

97% ^*data from raw suppliers

2-[4-(Benzyloxy)phenyl]benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)C3=CC=CC=C3C=O

Technology Process of 2-[4-(Benzyloxy)phenyl]benzaldehyde

There total 2 articles about 2-[4-(Benzyloxy)phenyl]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C39H33BiO3 + ortho-bromobenzaldehyde (6630-33-7) → 4'-(benzyloxy)-[1,1'-biphenyl]-2-carbaldehyde (893736-26-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In N,N-dimethyl acetamide; at 90 ℃; for 5h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4ra13348j

Reference yield: 80.0%

ortho-bromobenzaldehyde (6630-33-7) + [4-(benzyloxy)phenyl]boronic acid (146631-00-7) → 4'-(benzyloxy)-[1,1'-biphenyl]-2-carbaldehyde (893736-26-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2018.08.020

Reference yield:

4'-(benzyloxy)-[1,1'-biphenyl]-2-carbaldehyde (893736-26-0) + (2-oxo-2-p-tolylethyl)triphenylphosphonium bromide (2689-61-4) → C29H24O2 + C29H24O2

Guidance literature:

With caesium carbonate; In N,N-dimethyl acetamide; at 90 ℃; for 5h; Overall yield = 73 %; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4ra13348j

upstream raw materials:

ortho-bromobenzaldehyde

[4-(benzyloxy)phenyl]boronic acid