2689-61-4

Basic information

• Product Name: (2-oxo-2-p-tolylethyl)triphenylphosphonium bromide
• Synonyms: (2-oxo-2-p-tolylethyl)triphenylphosphonium bromide
• CAS NO: 2689-61-4
• Molecular Weight: 475.365
• Mol File: 2689-61-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: (2-oxo-2-p-tolylethyl)triphenylphosphonium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: (2-oxo-2-p-tolylethyl)triphenylphosphonium bromide(2689-61-4)
• EPA Substance Registry System: (2-oxo-2-p-tolylethyl)triphenylphosphonium bromide(2689-61-4)

Safety Data

• Hazardous Substances Data: 2689-61-4(Hazardous Substances Data)

Upstream product

• 122-00-9 para-methylacetophenone 
• 619-41-0 4-(bromoacetyl)toluene 
• 603-35-0 triphenylphosphine 

Downstream Products

• 1256284-88-4 2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256284-98-6 2-(5,9-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256284-99-7 2-(6,9-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256285-00-3 2-(7,9-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256285-01-4 2-(8,9-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256285-02-5 2-(5-fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256285-03-6 2-(5-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256285-04-7 2-(6-fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256285-05-8 2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256285-06-9 2-(8-chloro-6,9-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256285-07-0 1-p-tolyl-2-(6,8,9-trimethyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone 
• 19832-78-1 1-(4-methylphenyl)prop-2-en-1-one 
• 3837-95-4 (E)-1-(4-methylphenyl)-2-buten-1-one 
• 791-28-6 Triphenylphosphine oxide 

Relevant articles and documents

Substituent effects in the formation of a few acenaphthenone-2-ylidene ketones and their molecular docking studies and in silico ADME profile

We observed intriguing substituent effects in the reaction between 4-substituted acetophenones and acenaphthenequinone in the presence of KOH in methanol. In all cases, expected Claisen-Schimdt condensation was the first step. However, depending on the nature of 4-substituent on acetophenone, the initially formed condensation product remain unchanged or underwent Domino sequence of reactions to give three different 2:2 adducts arising through three distinct pathways. The interactions of acenaphthenone-2-ylidene ketones with the target proteins were performed by molecular docking studies. The prediction of in silico ADME belongings of the synthesized compounds revealed substantial drug-likeness characters based on Lipinski's rules.

One-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade

A one-pot synthesis of 2,5-disubstituted furans from γ-ketoacids is reported. In situ formation of allenoates by action of chloroformate on carboxylic acid following by enolization of ketone affords furan derivatives by cyclization. The reaction was extended to a wide scope of ketoacids and phosphonium salts. This methodology was applied on levulinic acid and derivatives, one of the biosourced platform chemicals.

Fe-Catalyzed Cycloisomerization of Aryl Allenyl Ketones: Access to 3-Arylidene-indan-1-ones

A cycloisomerization of aryl allenyl ketones to 3-arylidene-indan-1-ones using a cationic Fe-complex as a catalyst is reported. The catalyst opens a synthetically interesting reaction pathway to this surprisingly underrepresented class of indanones that are not accessible using alternative catalytic systems.