2-Fluoro-N-Methyl-5-nitroaniline

Base Information

• Chemical Name: 2-Fluoro-N-Methyl-5-nitroaniline
• CAS No.: 110729-51-6
• Molecular Formula: C7H7FN2O2
• Molecular Weight: 170.143
• Hs Code.: 2921490090
• Mol file: 110729-51-6.mol

Synonyms:2-Fluoro-N-Methyl-5-nitroaniline

Chemical Property of 2-Fluoro-N-Methyl-5-nitroaniline

Chemical Property:

• Boiling Point: 270.3±30.0 °C(Predicted)
• PKA: 2.12±0.25(Predicted)
• PSA: 57.85000
• Density: 1.361±0.06 g/cm3(Predicted)
• LogP: 2.37180

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-n-methyl-5-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-N-Methyl-5-nitroaniline can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process.

Technology Process of 2-Fluoro-N-Methyl-5-nitroaniline

There total 6 articles about 2-Fluoro-N-Methyl-5-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 6-fluoro-3-nitroaniline (369-36-8) → 2-fluoro-N,N-dimethyl-5-nitroaniline (110729-50-5) + 2-fluoro-N-methyl-5-nitroaniline (110729-51-6)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; water; at 20 ℃; for 18h;

Reference yield: 87.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 6-fluoro-3-nitroaniline (369-36-8) → 2-fluoro-N-methyl-5-nitroaniline (110729-51-6)

Guidance literature:

formaldehyd; 6-fluoro-3-nitroaniline; With sodium methylate; In methanol; at 20 ℃; for 16h;

With sodium tetrahydroborate; In methanol; for 0.25h;

Reference yield: 87.0%

C7H5FN2O2 → 2-fluoro-N-methyl-5-nitroaniline (110729-51-6)

Guidance literature:

With methanol; sodium tetrahydroborate; for 0.25h;

upstream raw materials:

formaldehyd

6-fluoro-3-nitroaniline

Downstream raw materials:

N-methyl-5-nitro-2-piperidinoaniline

N-methyl-5-nitro-2-[2-(1,2,3,4-tetrahydroisoquinolyl)]aniline

2-dimethylamino-N-methyl-5-nitroaniline

N-(2-Fluoro-5-nitro-phenyl)-N-methyl-methanesulfonamide

Refernces

• 1、 -. "mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY". Paragraph 0621; 0623. . Retrieved 2020/07/25.
• 2、 -. "Preparation method and applications of aromatic heterocyclic compound adopted as selective JAK3 and/or JAK1 kinase inhibitor". . . Retrieved 2016/10/08.