(13R)-3-Methoxyestra-1,3,5(10)-triene-17-one

Base Information

• Chemical Name: (13R)-3-Methoxyestra-1,3,5(10)-triene-17-one
• CAS No.: 17554-55-1
• Molecular Formula: C19H24O2
• Molecular Weight: 284.398
• Mol file: 17554-55-1.mol

Synonyms:(13R)-3-Methoxyestra-1,3,5(10)-triene-17-one;(13α)-3-Methoxy-1,3,5(10)-estratrien-17-one;(13α)-3-Methoxy-estra-1,3,5(10)-triene-17-one;(13α)-3-Methoxyestra-1,3,5(10)-triene-17-one;13α-Estrone-3-methyl ether

Chemical Property of (13R)-3-Methoxyestra-1,3,5(10)-triene-17-one

Chemical Property:

• PSA: 26.30000
• LogP: 4.12040

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (13R)-3-Methoxyestra-1,3,5(10)-triene-17-one

There total 72 articles about (13R)-3-Methoxyestra-1,3,5(10)-triene-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

estrone (53-16-7,474-84-0,517-06-6,1225-03-2,4413-09-6,4680-83-5,5285-27-8,15426-98-9,17337-44-9,19973-76-3,35937-97-4,35937-99-6,35938-00-2,94424-34-7,101976-76-5,107910-81-6) + 3-bromophenyltrimethylammonium iodide → O-methyl-estrone (1091-94-7,1624-62-0,1922-52-7,2445-27-4,6891-91-4,10003-03-9,13865-88-8,14088-31-4,15426-89-8,15426-95-6,15983-67-2,17554-55-1,17748-69-5,19592-58-6,36086-97-2,52193-72-3,55924-00-0,58072-52-9,58072-53-0,82467-78-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 3h; Solvent;

DOI:10.1039/d1sc00757b

Reference yield: 84.0%

estrone (53-16-7,474-84-0,517-06-6,1225-03-2,4413-09-6,4680-83-5,5285-27-8,15426-98-9,17337-44-9,19973-76-3,35937-97-4,35937-99-6,35938-00-2,94424-34-7,101976-76-5,107910-81-6) + N,N,N,2-tetramethylbenzenaminium iodide (35616-23-0) → O-methyl-estrone (1091-94-7,1624-62-0,1922-52-7,2445-27-4,6891-91-4,10003-03-9,13865-88-8,14088-31-4,15426-89-8,15426-95-6,15983-67-2,17554-55-1,17748-69-5,19592-58-6,36086-97-2,52193-72-3,55924-00-0,58072-52-9,58072-53-0,82467-78-5)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 3h;

DOI:10.1039/d1sc00757b

Reference yield: 65.0%

(+-)-estrone (1187829-63-5) + carbonic acid dimethyl ester (616-38-6) → 3-methoxy-estra-1,3,5(10)-trien-17-one (1091-94-7,1624-62-0,1922-52-7,2445-27-4,6891-91-4,10003-03-9,13865-88-8,14088-31-4,15426-89-8,15426-95-6,15983-67-2,17554-55-1,17748-69-5,19592-58-6,36086-97-2,52193-72-3,55924-00-0,58072-52-9,58072-53-0,82467-78-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; at 100 ℃; for 8h;

DOI:10.1055/s-1986-31642

upstream raw materials:

(+-)-estrone

carbonic acid dimethyl ester

estrone

methyl iodide

Downstream raw materials:

2-[3-Methoxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-(17E)-ylidene]-propionitrile

C₂₆H₃₀O₄S

methyl-[17ξ-hydroxy-13α-estratrien-(1.3.5(10))-yl-(3)]-ether

(2S,3S)-2-[3-(2-Dimethylaminomethyl-3-methoxy-phenyl)-3-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone

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