Methyl N-(4-methoxyphenyl)-beta-alaninate

Base Information

• Chemical Name: Methyl N-(4-methoxyphenyl)-beta-alaninate
• CAS No.: 42313-52-0
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.245
• Hs Code.: 2922509090
• Mol file: 42313-52-0.mol

Synonyms:Methyl N-(4-methoxyphenyl)-beta-alaninate

Chemical Property of Methyl N-(4-methoxyphenyl)-beta-alaninate

Chemical Property:

• PSA: 47.56000
• LogP: 1.74320

Purity/Quality:

99% ^*data from raw suppliers

methylN-(4-methoxyphenyl)-β-alaninate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl N-(4-methoxyphenyl)-beta-alaninate

There total 3 articles about Methyl N-(4-methoxyphenyl)-beta-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-aniline (104-94-9) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(4-methoxyphenylamino)propanoate (42313-52-0)

Guidance literature:

With silica-supported aluminum chloride; at 60 ℃; for 1.5h; Neat (no solvent);

DOI:10.1080/00397910802499559

Reference yield:

4-methoxy-aniline (104-94-9) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(4-methoxyphenylamino)propanoate (42313-52-0) + methyl 3-[(2-methoxycarbonylethyl)-4-methoxyphenylamino]propanoate (56525-67-8)

Guidance literature:

In 2,2,2-trifluoroethanol; water; at 80 ℃; for 16h;

DOI:10.1021/jo9012699

Reference yield:

→ methyl 3-(4-methoxyphenylamino)propanoate (42313-52-0)

Guidance literature:

upstream raw materials:

4-methoxy-aniline

acrylic acid methyl ester

Downstream raw materials:

3-[(3,5-Dibromo-2-diacetylamino-benzyl)-(4-methoxy-phenyl)-amino]-propionic acid methyl ester

N-(methoxycarbonylethyl)-N-(4-methoxyphenyl)-α-carbomethoxyacetamide

methyl N-tosyl-3-(4-methoxyanilino)propionate

3-(p-methoxyphenylamino)propionic hydrazide

Refernces

• 1、 Dai, Liyan,Zhang, Yi,Dou, Qianqian,Wang, Xiaozhong,Chen, Yingqi. "Chemo/regioselective Aza-Michael additions of amines to conjugate alkenes catalyzed by polystyrene-supported AlCl3". . p. 1712 - 1716. Retrieved 2013/03/13.
• 2、 Lad,Kulkarni,Desai,Wadgaonkar. "Lithium tetrafluoroborate catalyzed highly efficient inter- and intramolecular aza-Michael addition with aromatic amines". experimental part. p. 1059 - 1064. Retrieved 2012/03/11.