(4-Bromo-3-methoxyphenyl)boronic acid

Base Information

• Chemical Name: (4-Bromo-3-methoxyphenyl)boronic acid
• CAS No.: 1256345-59-1
• Molecular Formula: C₇H₈BBrO₃
• Molecular Weight: 230.854
• Hs Code.: 2931900090
• DSSTox Substance ID: DTXSID20681532
• Wikidata: Q82605604
• Mol file: 1256345-59-1.mol

Synonyms:4-Bromo-3-Methoxyphenylboronic Acid;1256345-59-1;(4-Bromo-3-methoxyphenyl)boronic acid;SCHEMBL8080504;DTXSID20681532;LCRYXSUMYJSZDG-UHFFFAOYSA-N;MFCD16036103;(4-Bromo-3-methoxyphenyl)boronicacid;4-bromo-3-methoxyphenyl boronic acid;AKOS015851833;BS-19723;CS-0139538;FT-0736082;N12676

Chemical Property of (4-Bromo-3-methoxyphenyl)boronic acid

Chemical Property:

• PSA: 49.69000
• LogP: 0.13750
• Storage Temp.: Room temperature.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 229.97499
• Heavy Atom Count: 12
• Complexity: 145

Purity/Quality:

98%min ^*data from raw suppliers

4-bromo-3-methoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=CC(=C(C=C1)Br)OC)(O)O

Technology Process of (4-Bromo-3-methoxyphenyl)boronic acid

There total 1 articles about (4-Bromo-3-methoxyphenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-iodo-2-methoxybenzene (755027-18-0) → (4-bromo-3-methoxyphenyl)boronic acid (1256345-59-1)

Guidance literature:

1-bromo-4-iodo-2-methoxybenzene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

With Triisopropyl borate; In diethyl ether; hexane; at -78 - 20 ℃; for 1.5h;

With hydrogenchloride; In diethyl ether; hexane; water; at 0 ℃; for 1h; Time;

Reference yield:

(4-bromo-3-methoxyphenyl)boronic acid (1256345-59-1) + 1-(2,3-dihydro-1H-inden-2-yl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine → 5-(4-amino-1-(2,3-dihydro-1H-inden-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-bromophenol

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 75 °C

2: boron tribromide / dichloromethane / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

Reference yield:

(4-bromo-3-methoxyphenyl)boronic acid (1256345-59-1) + 3-iodo-1-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine → 5-(4-amino-1-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-bromophenol

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1.5 h / 70 °C

2: boron tribromide / dichloromethane / 7.5 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

upstream raw materials:

1-bromo-4-iodo-2-methoxybenzene

Refernces