3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one

Base Information

Chemical Name:3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one
CAS No.:915307-81-2
Molecular Formula:C₁₂H₁₃Cl₂N₃O₂
Molecular Weight:302.16
Hs Code.:2933990090
Mol file:915307-81-2.mol

Synonyms:3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one;Pyrido[3,4-b]pyrazin-2(1H)-one, 3,7-dichloro-1-(2-propoxyethyl)-

Suppliers and Price of 3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one >95%
500mg
$ 964.00

Crysdot
3,7-Dichloro-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one 95+%
1g
$ 1138.00

AK Scientific
3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one
500mg
$ 1351.00

Total 3 raw suppliers

Chemical Property of 3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one

Chemical Property:

Boiling Point:458.0±55.0 °C(Predicted)
PKA:-0.22±0.20(Predicted)
PSA：57.01000
Density:1.43±0.1 g/cm3(Predicted)
LogP:2.52490

Purity/Quality:

98%min ^*data from raw suppliers

3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one

There total 7 articles about 3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1186508-07-5
7-chloro-1-(2-propoxy-ethyl)-1,4-dihydro-pyrido[3,4-b]pyrazine-2,3-dione

: 915307-81-2
3,7-dichloro-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2009.06.004

Reference yield: 66.0%

: 5781-53-3
monomethyl oxalyl chloride

: 915307-80-1
6-chloro-N₄-(2-propoxy-ethyl)-pyridine-3,4-diamine

: 915307-81-2
3,7-dichloro-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one

Guidance literature:: monomethyl oxalyl chloride; 6-chloro-N₄-(2-propoxy-ethyl)-pyridine-3,4-diamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

With sodium hydrogencarbonate; In dichloromethane; water;

With oxalyl dichloride; N,N-dimethyl-formamide; more than 3 stages;

Reference yield:

: 5350-93-6
6-Chloro-pyridin-3-ylamine

: 915307-81-2
3,7-dichloro-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,4-dioxane / 27 h / Reflux

2.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / diethyl ether; hexane / 2.67 h / -63 - -10 °C

2.2: 1 h / -60 - 0 °C

3.1: ethanol / 22 h / Reflux

4.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

5.2: 8 h / 105 °C

6.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 16 h / 130 °C

With hydrogenchloride; n-butyllithium; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.6b01666