5-Trifluoromethyl-piperidine-3-carboxylic acid methyl ester

Base Information

Chemical Name:5-Trifluoromethyl-piperidine-3-carboxylic acid methyl ester
CAS No.:1269755-53-4
Molecular Formula:C8H12F3NO2
Molecular Weight:211.184
Hs Code.:
Mol file:1269755-53-4.mol

Synonyms:5-Trifluoromethyl-piperidine-3-carboxylic acid methyl ester;methyl 5-(trifluoromethyl)piperidine-3-carboxylate

Suppliers and Price of 5-Trifluoromethyl-piperidine-3-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
Methyl5-(trifluoromethyl)piperidine-3-carboxylate 95%
1g
$ 1117.00

American Custom Chemicals Corporation
METHYL-5-(TRIFLUOROMETHYL)PIPERIDINE-3-CARBOXYLATE 95.00%
5MG
$ 456.92

Alichem
Methyl5-(trifluoromethyl)piperidine-3-carboxylate
1g
$ 1230.85

Alichem
Methyl5-(trifluoromethyl)piperidine-3-carboxylate
250mg
$ 492.34

Total 15 raw suppliers

Chemical Property of 5-Trifluoromethyl-piperidine-3-carboxylic acid methyl ester

Chemical Property:

PSA：38.33000
LogP:1.27620

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-(trifluoromethyl)piperidine-3-carboxylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Trifluoromethyl-piperidine-3-carboxylic acid methyl ester

There total 3 articles about 5-Trifluoromethyl-piperidine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

: 124236-38-0
methyl 5-(trifluoromethyl)nicotinate

: 1269755-53-4
methyl 5-(trifluoromethyl)piperidine-3-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; at 50 ℃;

Reference yield:

: 131747-40-5
5-(trifluoromethyl)pyridine-3-carboxylic acid

: 1269755-53-4
methyl 5-(trifluoromethyl)piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 18 h / 45 °C

2: hydrogen / palladium 10% on activated carbon; platinum(IV) oxide / acetic acid / 20 h / 25 °C / 10343.2 Torr

With thionyl chloride; hydrogen; platinum(IV) oxide; palladium 10% on activated carbon; In acetic acid;

Reference yield:

: 436799-33-6
3-bromo-5-(trifluoromethyl)pyridine

: 1269755-53-4
methyl 5-(trifluoromethyl)piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / 16 h / 120 °C / 22502.3 Torr / Autoclave

2: acetic acid; hydrogen; palladium 10% on activated carbon / 50 °C

With palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; hydrogen; palladium diacetate; acetic acid; triethylamine;