3,4-Dihydro-2,2-dimethyl-5-methoxy-6-acetyl-2H-1-benzopyran-7-ol

Base Information

• Chemical Name: 3,4-Dihydro-2,2-dimethyl-5-methoxy-6-acetyl-2H-1-benzopyran-7-ol
• CAS No.: 27364-68-7
• Molecular Formula: C14H18 O4
• Molecular Weight: 250.29
• Hs Code.: 2932999099
• Mol file: 27364-68-7.mol

Synonyms:7-Chromanol,6-acetyl-5-methoxy-2,2-dimethyl- (4CI); Ketone, 7-hydroxy-5-methoxy-2,2-dimethyl-6-chromanylmethyl (7CI,8CI); Dihydroevodionol; Isoacronylin

Chemical Property of 3,4-Dihydro-2,2-dimethyl-5-methoxy-6-acetyl-2H-1-benzopyran-7-ol

Chemical Property:

• PSA: 55.76000
• LogP: 2.70700

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dihydro-2,2-dimethyl-5-methoxy-6-acetyl-2H-1-benzopyran-7-ol

There total 12 articles about 3,4-Dihydro-2,2-dimethyl-5-methoxy-6-acetyl-2H-1-benzopyran-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3'-(3-hydroxy-3-methylbutyl)-4',6'-dihydroxyacetophenone (153399-41-8) → 6-Acetyl-3,4-dihydro-7-hydroxy-5-methoxy-2,2-dimethyl-2H-1-benzopyran (27364-68-7)

Guidance literature:

With toluene-4-sulfonic acid; In toluene;

DOI:10.1246/cl.1993.1895

Reference yield: 27.0%

Acetic acid 5-methoxy-2,2-dimethyl-chroman-7-yl ester (125116-28-1) → 8-Acetyl-7-hydroxy-5-methoxy-3,4-dihydro-2,2-dimethyl-2H-<1>benzopyran (4655-89-4) + 6-Acetyl-3,4-dihydro-7-hydroxy-5-methoxy-2,2-dimethyl-2H-1-benzopyran (27364-68-7)

Guidance literature:

With aluminium trichloride; In carbon disulfide; for 2h;

Reference yield:

4,6-dihydroxy-2-methoxyacetophenone (3602-54-8) + isoprene (78-79-5,9003-31-0) → 6-Acetyl-3,4-dihydro-7-hydroxy-5-methoxy-2,2-dimethyl-2H-1-benzopyran (27364-68-7) + 6-Acetyl-5-hydroxy-7-methoxy-3,4-dihydro-2,2-dimethyl-2H<1>benzopyran (32550-59-7)

Guidance literature:

With phosphoric acid; In xylene; at 30 - 35 ℃; for 20h; Yields of byproduct given;

DOI:10.1016/S0040-4020(01)92463-9

upstream raw materials:

6-acetyl-7-hydroxy-5-methoxy-2,2-dimethyl-2H-chromene

2-methyl-3-buten-2-ol

4,6-dihydroxy-2-methoxyacetophenone

3'-(3-hydroxy-3-methylbutyl)-4',6'-dihydroxyacetophenone

Downstream raw materials:

6-acetyl-7-benzyloxy-5-methoxy-2,2-dimethylchroman

6-Acetyl-7-benzoyloxy-3,4-dihydro-5-methoxy-2,2-dimethyl-2H-1-benzopyran

6-acetyl-7-hydroxy-5-methoxy-2,2-dimethyl-2H-chromene

2',4',5,5'-tetramethoxy-2,2-dimethylpyrano<5,6-g>isoflavone