DM1-SMCC

Base Information

Chemical Name:DM1-SMCC
CAS No.:1228105-51-8
Molecular Formula:C51H66ClN5O16S
Molecular Weight:1072.63
Hs Code.:
Mol file:1228105-51-8.mol

Synonyms:DM1-SMCC;N2'-Deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-maytansine;SMCC-DM1;DM1-SMC

Suppliers and Price of DM1-SMCC

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SMCC-DM1
1mg
$ 368.00

TRC
SMCC-DM1
10mg
$ 375.00

DC Chemicals
DM1-SMCC >98%
50 mg
$ 950.00

ChemScene
SMCC-DM1 98.18%
1mg
$ 120.00

ChemScene
SMCC-DM1 98.18%
5mg
$ 300.00

ChemScene
SMCC-DM1 98.18%
10mg
$ 516.00

ChemScene
SMCC-DM1 98.18%
100mg
$ 2640.00

ChemScene
SMCC-DM1 98.18%
50mg
$ 1860.00

ChemScene
SMCC-DM1 98.18%
25mg
$ 1068.00

Cayman Chemical
DM1-SMCC ≥98%
25mg
$ 750.00

Total 31 raw suppliers

Chemical Property of DM1-SMCC

Chemical Property:

PKA:9.82±0.70(Predicted)
PSA：282.83000
Density:1.41±0.1 g/cm3(Predicted)
LogP:4.44850
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

SMCC-DM1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description DM1-SMCC is a drug-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC.
Uses SMCC-DM1 is a mertansine drug (DM1) with a reactive linker SMCC to make antibody drug conjugate. DM1 (mertansine), a thiol-containing maytansinoid, is a potent microtubule-disrupting agent.

Technology Process of DM1-SMCC

There total 5 articles about DM1-SMCC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 77668-69-0
(1⁴S,1⁶S,3²R,3³R,2R,4S,10E,12E,14R)-8⁶-chloro-1⁴-hydroxy-8⁵,14-dimethoxy-3³,2,7,10-tetramethyl-1²,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate

: MPr-SMCC

: 1228105-51-8
SMCC-MDC

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

Reference yield:

: 57103-68-1
maytansinol

: 1228105-51-8
SMCC-MDC

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; scandium tris(trifluoromethanesulfonate) / dichloromethane / 0.5 h / -8 °C

1.2: 0.5 h / -8 - 20 °C

2.1: silica gel / dichloromethane; methanol / Resolution of racemate

3.1: piperidine / acetonitrile / 4 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With piperidine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane; acetonitrile;

Reference yield:

: 1452404-52-2
Fmoc-N-Me-L-Ala-maytansinol

: 1228105-51-8
SMCC-MDC

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / acetonitrile / 4 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With piperidine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile;