4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid

Base Information

Chemical Name:4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid
CAS No.:869886-90-8
Molecular Formula:C13H14ClN3O2
Molecular Weight:279.726
Hs Code.:
Mol file:869886-90-8.mol

Synonyms:4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid

Suppliers and Price of 4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-(5-Chloro-2-(isopropylamino)pyridin-4-yl)-1H-pyrrole-2-carboxylicacid 97%
1g
$ 327.00

Crysdot
4-(5-Chloro-2-(isopropylamino)pyridin-4-yl)-1H-pyrrole-2-carboxylicacid 97%
5g
$ 982.00

Matrix Scientific
4-(5-Chloro-2-(isopropylamino)pyridin-4-yl)-1H-pyrrole-2-carboxylicacid 97%
5g
$ 6480.00

Matrix Scientific
4-(5-Chloro-2-(isopropylamino)pyridin-4-yl)-1H-pyrrole-2-carboxylicacid 97%
10g
$ 11664.00

Total 7 raw suppliers

Chemical Property of 4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid

Chemical Property:

PSA：78.01000
LogP:3.32160

Purity/Quality:

99% ^*data from raw suppliers

4-(5-Chloro-2-(isopropylamino)pyridin-4-yl)-1H-pyrrole-2-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid

There total 14 articles about 4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 869886-89-5
4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(2,4,6-trimethylbenzenesulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester

: 869886-90-8
4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H pyrrole-2-carboxylic acid

Guidance literature:: 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(2,4,6-trimethylbenzenesulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; for 8h; Heating / reflux;

With hydrogenchloride; water; In tetrahydrofuran; Product distribution / selectivity;

Reference yield: 74.0%

: 869886-88-4
4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester

: 869886-90-8
4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H pyrrole-2-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; diethylamine; In tetrahydrofuran; water; at 15 - 70 ℃; for 30h; Inert atmosphere; Reflux; Large scale;

Reference yield:

: 659731-48-3
5-chloro-2-fluoro-4-iodopyridine

: 869886-90-8
4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 65 - 75 °C / Reflux; Inert atmosphere; Large scale

2: sodium carbonate; palladium diacetate; tricyclohexylphosphine tetrafluoroborate / water / 20 - 85 °C / Inert atmosphere; Reflux; Large scale

3: lithium hydroxide monohydrate; diethylamine / water; tetrahydrofuran / 30 h / 15 - 70 °C / Inert atmosphere; Reflux; Large scale

With lithium hydroxide monohydrate; palladium diacetate; sodium carbonate; diethylamine; tricyclohexylphosphine tetrafluoroborate; In tetrahydrofuran; ethanol; water;