3-CHLORO-2-HYDROXYPHENYL BORONIC ACID

Base Information

• Chemical Name: 3-CHLORO-2-HYDROXYPHENYL BORONIC ACID
• CAS No.: 951655-50-8
• Molecular Formula: C6H6BClO3
• Molecular Weight: 172.376
• Hs Code.: 2931900090
• Mol file: 951655-50-8.mol

Synonyms:3-CHLORO-2-HYDROXYPHENYL BORONIC ACID;Boronic acid, B-(3-chloro-2-hydroxyphenyl)-;3-Chloro-2-hydroxyMethylphenylboronic acid

Chemical Property of 3-CHLORO-2-HYDROXYPHENYL BORONIC ACID

Chemical Property:

• Boiling Point: 338.8±52.0 °C(Predicted)
• PKA: 7.63±0.58(Predicted)
• PSA: 60.69000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: -0.27460
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-2-hydroxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Chloro-2-hydroxyphenylboronic acid

Technology Process of 3-CHLORO-2-HYDROXYPHENYL BORONIC ACID

There total 1 articles about 3-CHLORO-2-HYDROXYPHENYL BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-chloro-2-methoxyphenyl)boronic acid (179898-50-1) → (3-chloro-2-hydroxyphenyl)boronic acid (951655-50-8)

Guidance literature:

(3-chloro-2-methoxyphenyl)boronic acid; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With methanol; In dichloromethane; at -78 ℃; Inert atmosphere;

DOI:10.1021/cc100068a

Reference yield: 34.0%

2,3-dibromopyridine (13534-89-9) + (3-chloro-2-hydroxyphenyl)boronic acid (951655-50-8) → 2-(3-bromopyridin-2-yl)-6-chlorophenol (1609373-88-7)

Guidance literature:

2,3-dibromopyridine; (3-chloro-2-hydroxyphenyl)boronic acid; With potassium carbonate; In 1,2-dimethoxyethane; water; for 0.166667h;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 5h; Reflux;

Reference yield:

ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (1128268-00-7) + (3-chloro-2-hydroxyphenyl)boronic acid (951655-50-8) → Ethyl 1-(6-(3-chloro-2-hydroxyphenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (1240970-83-5)

Guidance literature:

With sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In water; acetonitrile; at 70 ℃; for 18h; Inert atmosphere;

upstream raw materials:

(3-chloro-2-methoxyphenyl)boronic acid

Downstream raw materials:

Ethyl 1-(6-(3-chloro-2-hydroxyphenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

C₁₆H₁₄ClNO₃

2-(3-bromopyridin-2-yl)-6-chlorophenol

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