1H-pyrazole-4-carboxylic acid, 1-(6-chloropyridin-2-yl)-5-(trifluoroMethyl)-, ethyl ester

Base Information

• Chemical Name: 1H-pyrazole-4-carboxylic acid, 1-(6-chloropyridin-2-yl)-5-(trifluoroMethyl)-, ethyl ester
• CAS No.: 1128268-00-7
• Molecular Formula: C₁₂H₉ClF₃N₃O₂
• Molecular Weight: 319.671
• Mol file: 1128268-00-7.mol

Synonyms:ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Chemical Property of 1H-pyrazole-4-carboxylic acid, 1-(6-chloropyridin-2-yl)-5-(trifluoroMethyl)-, ethyl ester

Chemical Property:

• Boiling Point: 411.9±45.0 °C(Predicted)
• PKA: -4.62±0.10(Predicted)
• Density: 1.48±0.1 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

Ethyl1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-pyrazole-4-carboxylic acid, 1-(6-chloropyridin-2-yl)-5-(trifluoroMethyl)-, ethyl ester

There total 7 articles about 1H-pyrazole-4-carboxylic acid, 1-(6-chloropyridin-2-yl)-5-(trifluoroMethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

2,6-dichloropyridine (2402-78-0) + ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate (571-55-1) → ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (1128268-00-7)

Guidance literature:

2,6-dichloropyridine; With hydrazine; In ethanol; for 4h; Heating / reflux;

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate; In ethanol; for 3h; Heating / reflux;

Reference yield: 85.0%

(6-bromopyridin-2-yl)hydrazine (26944-71-8) + 2-[1-ethoxy-meth-(Z)-ylidene]-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester (1048670-08-1) → ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (1128268-00-7)

Guidance literature:

In tetrahydrofuran; at -20 - 20 ℃; for 2.25h;

Reference yield: 82.0%

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate (571-55-1) + (6-chloropyridin-2-yl)hydrazine (5193-03-3) → ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (1128268-00-7)

Guidance literature:

In ethanol; at 80 ℃; for 1h;

upstream raw materials:

(6-bromopyridin-2-yl)hydrazine

2-[1-ethoxy-meth-(Z)-ylidene]-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester

2,6-dichloropyridine

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

Downstream raw materials:

1-[6-(3,5-dichlorophenyl)-2-pyridinyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Ethyl 1-(6-{2-[(4-iodobenzyl)oxy]phenyl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Ethyl 1-(6-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

C₁₉H₁₅F₄N₃O₃

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