Methyl 2-(2-bromo-6-oxo-1-prop-2-ynylpyridin-4-yl)acetate

Base Information

Chemical Name:Methyl 2-(2-bromo-6-oxo-1-prop-2-ynylpyridin-4-yl)acetate
CAS No.:141807-55-8
Molecular Formula:C₁₁H₁₀BrNO₃
Molecular Weight:284.109
Hs Code.:
DSSTox Substance ID:DTXSID30401046
Wikidata:Q82204106
Mol file:141807-55-8.mol

Synonyms:141807-55-8;methyl 2-(2-bromo-6-oxo-1-prop-2-ynylpyridin-4-yl)acetate;Methyl 6-Bromo-1,2-dihydro-2-oxo-1-(2-propynyl)-4-pyridineacetate (85:15% Bromo:Chloro Derivative);Methyl 2-(6-bromo-2-oxo-1-(prop-2-yn-1-yl)-1,2-dihydropyridin-4-yl)acetate;METHYL 6-BROMO-1,2-DIHYDRO-2-OXO-1-(2-PROPYNYL)-4-PYRIDINEACETATE (85;METHYL 6-BROMO-1,2-DIHYDRO-2-OXO-1-(2-PROPYNYL)-4-PYRIDINEACETATE (85:15per cent BROMO:CHLORO DERIVA;starbld0002582;SCHEMBL5857035;DTXSID30401046;FT-0671570

Suppliers and Price of Methyl 2-(2-bromo-6-oxo-1-prop-2-ynylpyridin-4-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl6-Bromo-1,2-dihydro-2-oxo-1-(2-propynyl)-4-pyridineacetate(85:15%Bromo:ChloroDerivative)
100mg
$ 1110.00

Medical Isotopes, Inc.
Methyl6-Bromo-1,2-dihydro-2-oxo-1-(2-propynyl)-4-pyridineacetate(85:15%Bromo:ChloroDerivative)
50 mg
$ 1720.00

American Custom Chemicals Corporation
METHYL-6-BROMO-1,2-DIHYDRO-2-OXO-1-(2-PROPYNYL)-4-PYRIDINEACETATE 95.00%
5MG
$ 504.27

Total 1 raw suppliers

Chemical Property of Methyl 2-(2-bromo-6-oxo-1-prop-2-ynylpyridin-4-yl)acetate

Chemical Property:

Melting Point:103-106°C
PSA：48.30000
LogP:0.95950
Storage Temp.:-20°C Freezer
Solubility.:Chloroform, Dichloromethane, Methanol
XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:282.98441
Heavy Atom Count:16
Complexity:428

Purity/Quality:: Methyl6-Bromo-1,2-dihydro-2-oxo-1-(2-propynyl)-4-pyridineacetate(85:15%Bromo:ChloroDerivative) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)CC1=CC(=O)N(C(=C1)Br)CC#C
Uses Methyl 6-Bromo-1,2-dihydro-2-oxo-1-(2-propynyl)-4-pyridineacetate (85:15% Bromo:Chloro Derivative) (cas# 141807-55-8 ) is a compound useful in organic synthesis.

Technology Process of Methyl 2-(2-bromo-6-oxo-1-prop-2-ynylpyridin-4-yl)acetate

There total 6 articles about Methyl 2-(2-bromo-6-oxo-1-prop-2-ynylpyridin-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 141807-52-5
(6-Bromo-2-oxo-1,2-dihydro-pyridin-4-yl)-acetic acid methyl ester

: 106-96-7
propargyl bromide

: 141807-55-8
methyl 6-bromo-1,2-dihydro-2-oxo-1-(2-propynyl)-4-pyridineacetate

: (2-Bromo-6-prop-2-ynyloxy-pyridin-4-yl)-acetic acid methyl ester

Guidance literature:: With sodium hydride; lithium bromide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; Yields of byproduct given;
DOI:10.1016/0040-4039(95)01917-7

Reference yield: 70.0%

: 141807-52-5
(6-Bromo-2-oxo-1,2-dihydro-pyridin-4-yl)-acetic acid methyl ester

: 106-96-7
propargyl bromide

: 141807-55-8
methyl 6-bromo-1,2-dihydro-2-oxo-1-(2-propynyl)-4-pyridineacetate

Guidance literature:: With sodium hydride; lithium bromide; In 1,2-dimethoxyethane;
DOI:10.1021/ja00040a060

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 141807-55-8
methyl 6-bromo-1,2-dihydro-2-oxo-1-(2-propynyl)-4-pyridineacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent

2: 95 percent / NaOH / ethanol

3: 1.) PCl₅, 2.) HBr gas

4: 70 percent / NaH, LiBr / 1,2-dimethoxy-ethane

With sodium hydroxide; phosphorus pentachloride; hydrogen bromide; sodium hydride; lithium bromide; In 1,2-dimethoxyethane; ethanol;
DOI:10.1021/ja00040a060